| 张春阳,刘素珍,孙晶.综合康复训练联合美多巴治疗帕金森运动功能障碍 43例[J].安徽医药,2021,25(11):2252-2256. |
| 综合康复训练联合美多巴治疗帕金森运动功能障碍 43例 |
| Therapeutic effect of comprehensive rehabilitation training combined with madopar on mo? tor dysfunction in Parkinson's patients:43 cases |
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| DOI：10.3969/j.issn.1009-6469.2021.11.030 |
| 中文关键词: 帕金森病 康复训练 运动功能障碍 肌张力 美多巴 |
| 英文关键词: Parkinson's disease Rehabilitation training Motor dysfunction Muscle tone Madopar |
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| 中文摘要: |
| 目的分析综合康复训练联合美多巴对帕金森病( PD)病人运动功能障碍影响。方法选取 2018年 1月至 2019年 5月间在中国医科大学附属第一医院鞍山医院接受治疗的 PD病人 86例，随机数字表法分为对照组( 43例)服用美多巴，观察组(43例)在对照组基础上行综合康复训练，观察治疗前后病人临床疗效、运动症状、肌张力、生活质量改善情况和血清氧化应激指标情况。结果治疗后两组帕金森病综合评定量表( UPDRS)评分较治疗前降低，且观察组评分低于对照组，差异有统计学意义(P<0.05)；治疗后两组中文版生活质量评价量表(SF-36)评分较治疗前升高，肌张力评分较治疗前降低，且观察组 SF-36评分高于对照组［(99.50±6.17)分比( 93.52±6.10)分］肌张力评分低于对照组［(1.01±0.35)分比( 1.63±0.39)分］差异有统计学意义( P<0.05)；治疗后两组 Berg评分、简易上肢机能检，查( STEF)评分较治疗前升高， 10 m折返跑时间较治疗前降，低，且观察组 Berg评分［( 52.13±5.26)分比( 49.33±5.21)分］、 STEF评分［( 74.63±6.30)分比( 70.49±6.28)分］高于对照组， 10 m折返跑时间低于对照组［( 32.17±4.09)分比( 34.65±4.05)分］差异有统计学意义( P<0.05)；治疗后观察组血清丙二醛( MDA)、过氧化脂质(LPO)及 α-突触核蛋白(α-SYN)含量较治疗前、，对照组降低( P<0.05)。结论综合康复训练联合美多巴可有效改善 PD病人肌张力与运动功能，减轻机体氧化应激程度，提高病人生活质量。 |
| 英文摘要: |
| Objective To analyze the effect of comprehensive rehabilitation training combined with Madopar on motor dysfunctionin patients with Parkinson's disease (PD).Methods A total of 86 PD patients who were treated in Anshan Hospital, the First AffiliatedHospital of China Medical University from January 2018 to May 2019 were selected. The random number table method was used to divide the control group (43 cases) to take Madopar, and the observation group (43 cases) to the control group. Comprehensive rehabilitation training was used to observe the clinical efficacy, exercise symptoms, muscle tone, quality of life improvement and serum oxidativestress indicators of patients before and after treatment.Results After treatment, the UPDRS scores of the two groups were lower thanthose before treatment, and the score of the observation group was lower than that of the control group, the difference was statisticallysignificant (P<0.05); after treatment, the SF-36 score of the two groups of patients was higher than that before treatment, muscle tonescore was lower than that before treatment, and the SF-36 score of the observation group was higher than that of the control group [(99.50±6.17) vs. (93.52±6.10)], and the muscle tone score was lower than that of the control group.[(1.01±0.35) vs. (1.63±0.39)] The difference was statistically significant (P<0.05). After treatment, Berg score and STEF score of patients in the two groups were higher thanthose before treatment, and the 10 m reentry run time was lower than that before treatment. Berg score[(52.13±5.26) vs. (49.33±5.21)] and STEF score[(74.63±6.30) vs. (70.49±6.28)] of patients in the observation group were higher than those in the control group, and the10 m reentry run time was lower than that in the control group[(32.17±4.09) vs. (34.65±4.05)], the difference was statistically significant (P<0.05); after treatment, the content of MDA, LPO and α-SYN in serum of the observation group were lower than those before treatment and control group (P<0.05).Conclusion Comprehensive rehabilitation training combined with Madopar can effectively improvemuscle tone and motor function in PD patients, reduce the degree of oxidative stress in the body and improve the quality of life. |
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