| 王英豪,戴立英.新生儿坏死性小肠结肠炎与肠道微生物群落关系的研究进展[J].安徽医药,2021,25(12):2346-2350. |
| 新生儿坏死性小肠结肠炎与肠道微生物群落关系的研究进展 |
| Research progress between neonatal necrotizing enterocolitis and intestinal microbial community |
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| DOI：10.3969/j.issn.1009-6469.2021.12.004 |
| 中文关键词: 小肠结肠炎，坏死性 婴儿，新生 肠道微生物群落 变形杆菌 婴儿，早产 免疫应答 |
| 英文关键词: Enterocolitis, necrotizing Infant, newborn Intestinal microbial community Gammaproteobacteria Infant, pre. mature Immune response |
| 基金项目:西藏自治区卫生和计划生育委员会、财政厅、科技厅 2017年第三批前 50个组援医学项目( XZ2017ZR-ZYZ05) |
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| 中文摘要: |
| 新生儿坏死性小肠结肠炎( NEC)是新生儿重症监护病房( NICU)最常见的胃肠道急症，病死率达 30%，多见于早产儿，尤其是超低出生体质量儿，典型表现为回肠末端及结肠近端出现炎症及坏死，虽然目前 NEC发病机制尚不完全清楚，但随着 NEC研究的不断深入，越来越多的证据表明肠道微生物群落紊乱早于 NEC发生，肠道的炎症及坏死也干扰肠道微生物群部落的平衡。本研究对近年新生儿肠道微生物群落与 NEC之间关系的研究进行综述。 |
| 英文摘要: |
| Neonatal necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency in neonatal intensive care unit(NICU), and the case fatality rate is as high as 30%. NEC is more common in premature infants, especially those with very low birthweight, and its typical manifestations are the distal ileum and proximal colon inflammation and necrosis. Although at present the patho.genesis of NEC is not entirely clear, as the research going, intensive evidence suggests that the disturbance of intestinal microbial com.munity occurred earlier than NEC, and intestinal inflammation and necrosis also interfered with the balance of intestinal microbial com.munity. The relationship between neonatal intestinal microbial community and NEC was reviewed in this study. |
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