| 温雅,王珊,刘琦,等.帕金森病病人血清白细胞介素 -6、白细胞介素 -1β及肿瘤坏死因子 α水平变化及其临床意义[J].安徽医药,2022,26(1):54-57. |
| 帕金森病病人血清白细胞介素 -6、白细胞介素 -1β及肿瘤坏死因子 α水平变化及其临床意义 |
| Changes and clinical significance of serum interleukin-6, interleukin-1β and tumor necrosis factor α in patients with Parkinson's disease |
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| DOI：10.3969/j.issn.1009-6469.2022.01.012 |
| 中文关键词: 帕金森病 白细胞介素 -6 白细胞介素 -1β 肿瘤坏死因子 α 认知功能 |
| 英文关键词: Parkinson disease Interleukin-6 Interleukin-1β Tumor necrosis factor-α Cognitive function |
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| 中文摘要: |
| 目的分析帕金森病病人血清白细胞介素( IL)-6、IL-1β及肿瘤坏死因子 α(TNF-α)水平变化及其临床意义。方法 2015年 6月至 2019年 6月河北医科大学第二医院诊治帕金森病 94例作为观察组、健康体检者 50例作为对照组，采用 ELISA法检测两组受试者血清 IL-6、IL-1β及 TNF-α含量，分析其在帕金森病病人中的临床意义。结果观察组病人血清 IL-6、IL-1β及 TNF-α水平明显高于对照组［( 18.53±2.14)pg/mL比( 3.26±0.52)pg/mL，(183.26±15.40)pg/mL比(.21.57±3.55)pg/mL，(376.19± |
| 英文摘要: |
| Objective To analyze the changes and clinical significance of serum interleukin (IL)-6, IL-1β and tumor necrosis factor α (TNF-α) in patients with Parkinson's disease (PD).Methods A total of 94 patients with PD treated in Second Hospital of HebeiMedical University from June 2015 to June 2019 were enrolled as observation group, while other 50 healthy controls were enrolled ascontrol group. The levels of serum IL-6, IL-1β and TNF-α in both groups were detected by ELISA. Their clinical significance in PD pa-tients was analyzed.Results The levels of serum IL-6, IL-1β and TNF-α in the observation group were significantly higher than those in the control group [(18.53±2.14) pg/mL vs. (3.26±0.52) pg/mL, (183.26±15.40) pg/mL vs. (21.57±3.55) pg/mL, (376.19±32.07) pg/mL vs. ( 207.11±17.21) pg/mL, P<0.05]. The levels of IL-6, IL-1β and TNF-α, and MoCA score in PD patients with cognitive dysfunctionwere significantly higher than those with normal cognitive function [(21.37±2.73) pg/mL vs. (17.14±2.06) pg/mL, (196.41±17.85) pg/mL vs. (175.23±14.11) pg/mL, (408.52±35.49) pg/mL vs. ( 361.24±30.55) pg/mL, (28.47±2.87) points vs. (21.32±1.45) points, P<0.05]. There was no significant difference in levels of serum IL-6, IL-1β and TNF-α among PD patients with different Hoehn Yahr grading (P> 0.05). The levels of IL-6, IL-1β and TNF-α in PD patients were positively correlated with MoCA score (P<0.05), while not significantly correlated with Hoehn Yahr grading (P>0.05).Conclusion The levels of serum IL-6, IL-1β and TNF-α are high in PD patients, which are closely related to cognitive function. However, they cannot reflect disease severity. |
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