| 张策,尹忠诚,沈男,等.儿童青少年肥胖分布及其与肾功能的关系[J].安徽医药,2022,26(2):270-273. |
| 儿童青少年肥胖分布及其与肾功能的关系 |
| Distribution of obesity in children and adolescents and its relationship with renal function |
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| DOI：10.3969/j.issn.1009-6469.2022.02.015 |
| 中文关键词: 超重 儿童肥胖 肥胖症 青少年 尿酸 肾小球滤过率 |
| 英文关键词: Overweight Pediatric obesity Obesity Adolescent Uric acid Estimated glomerular filtration rate |
| 基金项目:宿迁市科技创新专项重点研发项目( S201907)；江苏省妇幼健康科研项目( F201941) |
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| 中文摘要: |
| 目的探讨儿童青少年肥胖分布特点及其与儿童早期肾功能损害的关系。方法选取 2019年 9月宿迁市 6所中小学资料完整的 3 154名学生进行横断面调查，测量身高、体质量并检测尿素氮( BUN)、肌酐( CR)和尿酸( UA)，计算肾小球滤过率(eGFR)。比较不同体质量组的肾功能，分析体质指数( BMI)与肾功能的相关性，比较不同性别和年龄组的肥胖率，分析超重肥胖和肾小球滤过率异常的关系。结果儿童青少年超重肥胖存在性别和年龄差异，男生超重［246(15.14%)例比 171 |
| 英文摘要: |
| Objective To investigate the distribution of obesity in children and adolescents and explores its relationship with the re. nal function.Methods A cross-sectional survey was conducted on 3 154 students with complete data from 6 primary and secondaryschools in Suqian city in September 2019. Height, body weight, urea nitrogen (BUN), creatinine (CR) and uric acid (UA) were mea.sured, and glomerular filtration rate (eGFR) was calculated. The renal function of different body weight groups was compared, the rela.tionship between body mass index (BMI) and renal function was analyzed. The obesity rate of different genders and age groups was com.pared, and the relationship between overweight and obesity and abnormal glomerular filtration rate was analyzed.Results There were gender and age differences in overweight and obesity among children and adolescents. The overweight and obesity rate of boys werehigher than those of girls [246 (15.14%) vs. 171 (11.18%), 204 (12.56%) vs. 103 (6.74%) ,χ2=46.47,P<0.001]. Children of 12-year-old group have the highest overweight rate (27.90%) while 6-year-old group have the lowest obesity rate (9.96%). BMI was positively corre.lated with UA and Cr after adjustment for the age and gender (partial relation coefficient R was 0.290 and 0.049, P<0.05). There were statistically significant differences in UA and eGFR among different body weight groups (P<0.05), and UA and eGFR increased gradu. ally with the increase of body weight (P<0.05). After adjusting for age and gender, obesity significantly increased the risk of abnormally elevated eGFR, with an OR (95%CI) of 1.324 (1.035-1.692), P=0.029.Conclusions There are gender and age differences in over.weight and obesity in children and adolescents. Obesity in children and adolescents is a risk factor for early glomerular hyperfiltration,and the related pathological mechanism needs further study. |
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