| 陈艳红,谢云霞,刘涛.血清脂肪酸合酶、上皮钙黏素、再生蛋白 4水平在早期胃癌中的诊断价值及与淋巴结转移的关系[J].安徽医药,2022,26(2):321-325. |
| 血清脂肪酸合酶、上皮钙黏素、再生蛋白 4水平在早期胃癌中的诊断价值及与淋巴结转移的关系 |
| Diagnostic value of serum fatty acid synthase, E-cadherin and REG4 levels in patients with early gastric cancer and their relationship with lymph node metastasis |
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| DOI：10.3969/j.issn.1009-6469.2022.02.027 |
| 中文关键词: 胃肿瘤 早期诊断 脂肪酸合酶 上皮钙黏素 再生蛋白 4 淋巴结转移 |
| 英文关键词: Stomach neoplasms Early diagnosis Fatty acid synthase E-cadherin Regenerated protein 4 Lymph node me. tastasis |
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| 中文摘要: |
| 目的探讨血清脂肪酸合酶( FAS)、上皮钙黏素( E-cadherin)、再生蛋白 4(REG4)水平在早期胃癌中的诊断价值及与淋巴结转移的关系。方法选取郑州大学第一附属医院 2014年 1月至 2016年 8月收治的胃癌病人 88例作为观察组，其中淋巴结转移病人 35例，无淋巴结转移病人 53例，另选取同期胃良性疾病病人 80例作为对照组。检测对比两组、有无淋巴结转移病人血清 FAS、E-cadherin、REG4水平，分析各血清诊断价值及胃癌淋巴结转移的影响因素。随访 3年，比较不同血清 FAS、E-cadherin、REG4表达水平病人生存状况。结果观察组血清 FAS［( 62.38±20.79)ng/mL比( 41.90±13.92)ng/mL］、 REG4水平［(5.93±1.97)ng/mL比( 3.06±1.00)ng/mL］高于对照组， E-cadherin水平低于对照组［(3.57±1.01)μg/mL比(8.36±2.78)μg/mL］(P<0.001)。对于早期胃癌的诊断价值而言， E-cadherin AUC(0.793)>REG4(0.747)>FAS(0.735)三指标联合应用的价值更高，其灵敏度和特异度分别为 93.18%(82/88)、 93.75%(75/80)。有淋巴结转移病人血清 FAS、REG4水，平高于无淋巴结转移病人， E-cadherin水平低于无淋巴结转移病人( P<0.001)。低分化、肿瘤最大径 ≥5 cm、黏膜下癌、血清 FAS≥62.38 ng/mL、E-cadherin≤ 3.57μg/mL、REG4≥5.93 ng/mL是胃癌淋巴结转移的重要影响因素( P<0.05)。随访 3年， FAS、E-cadherin、REG4高表达组、低表达组生存曲线对比，差异有统计学意义( P<0.05)。结论血清 FAS、E-cadherin、REG4水平可考虑作为诊断胃癌的潜在有效肿瘤标志物，其水平异常表达是胃癌淋巴结转移的独立危险因素。 |
| 英文摘要: |
| Objective To investigate the diagnostic value of serum fatty acid synthase (FAS), E-cadherin (E-cadherin), and regener. ating islet-derived 4 (REG4) levels in patients with early gastric cancer (EGC) and their relationship with lymph node metastasis.Meth. ods Eighty-eight patients with EGC who were treated in the First Affiliated Hospital of Zhengzhou University from January 2014 toAugust 2016 were selected as the observation group, including 35 patients with lymph node metastasis, 53 patients without lymph nodemetastasis, and 80 patients with early gastric cancer during the same period were selected as the control group. Serum levels of FAS, E-cadherin, and REG4 in patients with and without lymph node metastasis were compared in the two groups, the diagnostic value of eachserum and the influencing factors of EGC lymph node metastasis were analyzed. Follow-up for 3 years, the survival status of patients with different serum FAS, E-cadherin, and REG4 levels were compared. Results Serum levels of FAS [(62.38±20.79) ng/mL vs. (41.90±13.92) ng/mL] and REG4 [(5.93±1.97) ng/mL vs. (3.06±1.00) ng/mL] in the observation group were higher than those in the con. trol group, and E-cadherin levels were lower than those in the control group [(3.57±1.01) μg/mL vs. (8.36±2.78) μg/mL] (P<0.001). For the diagnostic value of early gastric cancer: E-cadherin AUC (0.793) > REG4 (0.747) > FAS (0.735), the combined application of thethree indicators had higher value, and its sensitivity and specificity were 93.18% (82/88) and 93.75% (75/80), respectively. Serum FASand REG4 levels of patients with lymph node metastasis were higher than those without lymph node metastasis, and E-cadherin levels were lower than those without lymph node metastasis (P<0.001). Poorly differentiated, tumor diameter ≥5 cm, submucosal cancer, se. rum FAS≥62.38 ng/mL, E-cadherin≤3.57μg/mL, REG4≥5.93 ng/mL were important influencing factors of lymph node metastasis in EGC (P<0.05). After 3 years of follow-up, the survival curves of FAS, E-cadherin, and REG4 high expression groups and low expression groups were compared, and the difference was statistically significant (P<0.05).Conclusion Serum FAS, E-cadherin, and REG4 lev.els can be considered as potentially effective tumor markers for the diagnosis of EGC, abnormal expression of these levels is an indepen.dent risk factor for EGC lymph node metastasis. |
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