| 张贵,尚蕾,李晓玲,等.结肠癌转移相关基因 1、磷酸化需肌醇酶 1蛋白在鼻咽癌组织中表达及与其临床病理特征、放疗敏感度及预后的关系[J].安徽医药,2022,26(2):360-364. |
| 结肠癌转移相关基因 1、磷酸化需肌醇酶 1蛋白在鼻咽癌组织中表达及与其临床病理特征、放疗敏感度及预后的关系 |
| The expressions of MACC1 and p-ire1 in nasopharyngeal carcinoma and their relationship with clinicopathological characteristics, radiotherapy sensitivity and prognosis |
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| DOI：10.3969/j.issn.1009-6469.2022.02.036 |
| 中文关键词: 鼻咽肿瘤 病理状态，体征和症状 结肠癌转移相关基因 1 磷酸化需肌醇酶 1 病理 预后 |
| 英文关键词: Nasopharyngeal neoplasms Pathological conditions, signs and symptoms MACC1 p-IRE1 Pathological Prog. nosis |
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| 中文摘要: |
| 目的探讨结肠癌转移相关基因 1(MACC1)、磷酸化需肌醇酶 1(p-IRE1)蛋白在鼻咽癌组织中的表达情况及与鼻咽癌临床病理特征、放疗敏感度及预后的关系，为寻求个体化治疗提供依据。方法选取 2016年 1月至 2018年 12月在南阳市中心医院行根治性调强放疗的鼻咽癌病人癌组织标本 62例为鼻咽癌组，同时选取同期 20例健康人鼻咽部黏膜组织标本作为正常对照组，应用免疫组化法分别检测组织中 MACC1、p-IRE1蛋白的表达情况，分析其与鼻咽癌病人临床病理特征、放疗敏感度及预后的关系，以及鼻咽癌组织中 MACC1、p-IRE1蛋白阳性表达的相关性。结果鼻咽癌组织标本 MACC1、p-IRE1蛋白阳性表达率均明显高于正常鼻咽部黏膜组织标本，均差异有统计学意义( 70.97%比 15.00%，66.13%比 10.00%，P<0.05)。鼻咽癌组织 MACC1、p-IRE1蛋白阳性表达与 TNM临床分期和分化程度密切相关( P<0.05)，鼻咽癌组织 MACC1、p-IRE1蛋白阳性表达者放疗敏感度均明显低于阴性表达者，差异有统计学意义( P<0.05)。鼻咽癌组织 MACC1及 p-IRE1蛋白阳性表达呈显著正相关( χ2 =12.18，P<0.001，列联系数 =0.405)。放疗后随访期间有 12例( 19.35%)出现局部复发， 14例( 22.58%)出现远处转移；死亡 24例 |
| 英文摘要: |
| Objective To investigate the relationship between the expression of MACC1 and p-ire1 in nasopharyngeal carcinomaand its clinicopathological characteristics, radiotherapy sensitivity and prognosis, so as to provide reference for individual treatment.Methods From January 2016 to December 2018, 62 cancer tissue samples from nasopharyngeal carcinoma patients receiving radical intense-modulated radiotherapy in Nanyang Central Hospital were selected as the nasopharyngeal carcinoma group. Meanwhile, 20samples of nasopharyngeal mucosal tissue of healthy patients during the same period were selected as the normal control group.Immuno.histochemistry was used to detect the expression of MACC1 and p-ire1 proteins in tissues respectively, and to analyze the relationshipbetween them and the clinicopathological characteristics, radiotherapy sensitivity and prognosis of NPC patients, as well as the correla.tion between the positive expression of MACC1 and p-ire1 proteins in NPC tissues.Results The positive expression rates of MACC1 and p-ire1 in nasopharyngeal carcinoma tissues were significantly higher than those in normal nasopharyngeal mucosal tissues, with sta.tistically significant differences (70.97% vs. 15.00%,66.13% vs. 10.00%,P<0.05). The positive expressions of MACC1 and p-ire1 in na. sopharyngeal carcinoma tissues were closely related to TNM clinical stage and differentiation degree (P<0.05). The radiotherapy sensi. tivity of the patients with positive expressions of MACC1 and p-ire1 in nasopharyngeal carcinoma tissues was significantly lower thanthat of the patients with negative expressions, and the differences were statistically significant (P<0.05).The positive expression of MACC1 and p-ire1 in nasopharyngeal carcinoma was significantly positively correlated (χ2=12.18, P=0.000, association number= 0.405). During follow-up after radiotherapy, local recurrence occurred in 12 patients (19.35%) and distant metastasis occurred in 14 pa.tients (22.58%).There were 24 deaths (38.71%), all due to local recurrence or distant metastasis. Death after radiotherapy in nasopha.ryngeal carcinoma patients was closely related to TNM clinical stage, differentiation degree and MACC1 and p-ire1 protein expression in nasopharyngeal carcinoma tissues (P<0.05). The results of multivariate COX regression analysis showed that TNM clinical stage and positive expression of MACC1 and p-ire1 in nasopharyngeal carcinoma tissues were independent risk factors for the death of nasopha.ryngeal carcinoma patients after radiotherapy (P<0.05).Conclusions The detection of MACC1 and p-ire1 proteins in nasopharyngealcarcinoma patients may help to determine the clinical stage, pathological differentiation degree and radiotherapy sensitivity of nasopha.ryngeal carcinoma patients. Their positive expression is an independent risk factor for the prognosis of nasopharyngeal carcinoma, andmay become a new target for nasopharyngeal carcinoma gene therapy. |
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