| 刘丹丹,王亚峰.红细胞分布宽度与儿童过敏性紫癜肾炎病情预后的相关性分析[J].安徽医药,2022,26(3):496-500. |
| 红细胞分布宽度与儿童过敏性紫癜肾炎病情预后的相关性分析 |
| Association analysis between red blood cell distribution width and prognosis ofHenoch-Sch?nlein purpura nephritis in children |
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| DOI：10.3969/j.issn.1009-6469.2022.03.017 |
| 中文关键词: 紫癜，过敏性 儿童 过敏性紫癜肾炎 红细胞分布宽度 蛋白尿 相关性 |
| 英文关键词: Purpura, schoenlein-henoch Children Henoch-Sch?nlein purpura nephritis Red blood cell distribution width Proteinuria Correlation |
| 基金项目:河南省医学科技攻关计划联合共建项目( LHGJ20190934) |
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| 中文摘要: |
| 目的探讨红细胞分布宽度(RDW)与儿童过敏性紫癜肾炎( HSPN)病情轻重程度的相关性。方法回顾性分析 2016年 1月至 2018年 12月在郑州大学附属儿童医院肾脏风湿科住院的 HSPN病儿的资料，同时以同期健康体检儿童作为对照组。分析 HSPN病儿在入院时和对照组在体检时的白细胞计数、血红蛋白、血小板、 RDW、红细胞沉降率( ESR)和 24 h尿蛋白定量。同时根据肾活检肾小球病理的分级标准，比较不同病理分级 HSPN病儿的临床及实验室检测指标。结果两组资料共纳入 182例，其中 HSPN病儿 82例，健康对照组 100例。 HSPN组病儿的白细胞［( 11.50±4.12)×109/L比( 6.60±1.18)×109/L］、血小板［( 270±96)×109/L比( 227±73)×109/L］、 RDW［(13.30±0.49)%比( 13.08±0.73)%］和 ESR［( 12±4)mm/h比( 7±2)mm/h］均明显高于健康对照组( P<0.05)。白细胞、血小板、 ESR在不同病理分级病儿中差异无统计学意义( P>0.05)，而血红蛋白、 RDW和 24 h尿蛋白定量则差异有统计学意义( P<0.05)。logistic回归分析后显示 RDW(OR=5.787，P=0.021)和 24 h尿蛋白定量( OR=1.046，P= |
| 英文摘要: |
| Objective To investigate the association between red blood cell distribution width (RDW) and prognosis of Henoch-Sch?nlein purpuric nephritis (HSPN) in children.Methods The data from hospitalized HSPN patients from January 2016 to December2018 in the Department of Nephrology and Rheumatology of Children′s Hospital Affiliated to Zhengzhou University were retrospectiveanalyzed, and healthy children who underwent physical examination during the same period were selected as the control group. Whiteblood cell (WBC) counts, hemoglobin (HGB), platelet (PLT), RDW, erythrocyte sedimentation rate (ESR), and 24-hour urine protein level were analyzed at admission for HSNP patients and the control group children. According to the grade criteria of renal biopsy pathology, the clinical data and laboratory test indicators of children with different pathological grades of HSPN were compared.Results A total of 182 cases were included in the two groups, including 82 children with HSPN and 100 healthy children. The WBC [(11.50±4.12)×109/L vs. (6.60±1.18)×109/L], PLT [(270±96)×109/L vs. (227±73)×109/L] , RDW [(13.30±0.49)% vs. (13.08±0.73)%], and ESR [(12±4) mm/h vs. (7±2)mm/h] in the HSPN group were significantly higher than those in the healthy control group (P<0.05). There was no significant difference in WBC, PLT and ESR in children with different pathological grades (P>0.05), while there were statistical differences in HGB, RDW and 24h urine protein level (P<0.05). Logistic regression analysis showed that RDW (OR=5.787, P=0.021) and 24h urine protein level (OR=1.046, P=0.008) were risk factors for different grades of renal biopsy in HSPN children. The ROC curveshowed that the area under the curve was 0.793, P<0.001, when the cut-off value was 13.35%, the sensitivity of RDW in predicting thedifferent renal biopsy pathological grades in children with HSPN was 62.3%, and the specificity was 90.5%. The level of RDW in thenephrotic range proteinuria group was significantly higher than that in the non-nephrotic range proteinuria group (P<0.001). There was a positive correlation between RDW and 24h urine protein level (r=0.454, P<0.001).Conclusion RDW is elevated in children with HSPN, and it might be an early warning marker for the assessment of HSPN in children. |
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