| 黄鹂,徐寅鹏,李方,等.复方甘草酸苷联合西咪替丁治疗小儿过敏性紫癜有效性和安全性的 Meta分析[J].安徽医药,2022,26(4):637-643. |
| 复方甘草酸苷联合西咪替丁治疗小儿过敏性紫癜有效性和安全性的 Meta分析 |
| Meta-analysis of the efficacy and safety of compound glycyrrhizin combined with cimetidine in the treatment of children with anaphylactoid purpura |
| |
| DOI：10.3969/j.issn.1009-6469.2022.04.001 |
| 中文关键词: 紫癜，过敏性 复方甘草酸苷 西咪替丁 随机对照试验 儿童 Meta分析 |
| 英文关键词: Purpura,anaphylactoid Compoundglycyrrhizin Cimetidine Randomizedcontrolledtrial Children Meta-analysis |
| 基金项目: |
|
| 摘要点击次数: 1563 |
| 全文下载次数: 429 |
| 中文摘要: |
| 目的对复方甘草酸苷联合西咪替丁治疗过敏性紫癜儿科病人的临床安全性和有效性进行系统评价。方法使用计算机检索万方数据库、中国知网数据库、维普数据库、 The Cochrane Library、Pubmed，检索时间从建库至 2020年 3月，纳入复方甘草酸苷制剂联合西咪替丁对过敏性紫癜病儿设计的随机对照试验( RCT)由两名独立评价员分别选择试验并且评价质量，提取有效数据后采用 RevMan 5.3.3版本软件进行荟萃分析。结果共纳入 17个，临床对照试验研究，收集到病例 1 394例，荟萃分析研究结果表明，对过敏性紫癜的儿科病人，与对照组相比，使用复方甘草酸苷制剂联合西咪替丁进行治疗的试验组有效率更高( OR=5.85，95%CI:4.02～8.52，P<0.05)、紫癜相关症状消失时间更短( SMD= 2.18，95%CI: 2.75～ 1.61，P<0.05)、关节相关症状恢复时间更短( SMD= 1.93，95%CI: 2.40～ 1.46，P<0.05)、消化道相关症状恢复时间更短( SMD= 2.13，95%CI: 2.71～ 1.55，P<0.05)、肾功能损害恢复时间更短( SMD= 1.88，95%CI: 2.12～ 1.63，P<0.05)、住院时间更短( SMD= 2.85，95%CI: |
| 英文摘要: |
| Objective A systematic review on the clinical safety and efficacy of compound glycyrrhizin combined with cimetidine inthe treatment of pediatric patients with anaphylactoid purpura.Methods From the establishment of the database to March 2020, Wan fang, CNKI, VIP, Cochrane Library and PubMed databases were searched to include randomized controlled trials (RCTs) of compoundglycyrrhizin preparation combined with cimetidine in children with anaphylactoid purpura. Two independent reviewers selected the trialsand evaluated the quality. After extracting valid data, RevMan 5.3.3 software was used for meta-analysis.Results A total of 17 clinical controlled trials were included and 1 394 cases were collected. The results of the meta-analysis showed that compared with the controlgroup, the experimental group of pediatric patients with anaphylactoid purpura treated with compound glycyrrhizin preparation combinedwith cimetidine had a higher effective rate (OR = 5.85, 95% CI: 4.02 to 8.52, P < 0.05), a shorter purpura-related symptom disappearance time (SMD= 2.18, 95%CI: 2.75 to 1.61, P < 0.05), a shorter joint-related symptom recovery time (SMD = 1.93, 95%CI: 2.40 to 1.46, P<0.05), a shorter gastrointestinal symptom recovery time (SMD= 2.13, 95%CI: 2.71 to 1.55,P<0.05), a shorter renal impairment re covery time (SMD= 1.88,95%CI: 2.12 to 1.63, P<0.05), and a shorter hospital stay (SMD= 2.85, 95%CI: 3.21 to 2.49, P<0.05). Interms of the incidence of adverse reactions, compared with the control group, there was no significant difference in the incidence of ad verse reactions in the experimental group of pediatric patients with anaphylactoid purpura treated with compound glycyrrhizin prepara tion combined with cimetidine (OR=0.77, 95%CI:0.43 to 1.37, P>0.05).Conclusions Compound glycyrrhizin combined with cimeti dine has an obvious therapeutic effect on pediatric patients with anaphylactoid purpura. Although the adverse drug reaction was mild andthe safety factor was high, more high-quality, rigorous, multicenter, large-sample RCTs are required for verification. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
