| 袁燕,郭双喜,王聪聪.心肌肌钙蛋白 Ⅰ、神经元特异性烯醇酶及 S-100β蛋白对急性一氧化碳中毒后迟发性脑病的预测价值[J].安徽医药,2022,26(4):714-717. |
| 心肌肌钙蛋白 Ⅰ、神经元特异性烯醇酶及 S-100β蛋白对急性一氧化碳中毒后迟发性脑病的预测价值 |
| Predictive value of cardiac troponin I, neuron-specific enolase and S-100β protein in delayed encephalopathy after acute carbon monoxide poisoning |
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| DOI：10.3969/j.issn.1009-6469.2022.04.017 |
| 中文关键词: 一氧化碳中毒 缺氧，脑 心肌肌钙蛋白 Ⅰ 神经元特异性烯醇酶 S-100β蛋白 迟发性脑病 |
| 英文关键词: Carbon monoxide poisoning Hypoxia, brain Cardiac troponin I Neuron-specific enolase S-100β protein De-layed encephalopathy |
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| 目的探讨血清心肌肌钙蛋白 Ⅰ(cTnⅠ)、神经元特异性烯醇酶( NSE)及中枢神经特异性蛋白( S-100β)与急性一氧化碳中毒( ACOP)程度的关系以及对一氧化碳中毒后迟发性脑病( DEACMP)的预测价值。方法选择 2017年 6月至 2019年 6月新乡医学院第一附属医院收治的 68例 ACOP病人为 ACOP组，同时选择此期间在该院体检的 40例健康受试者为健康对照组，检测并记录 ACOP病人入院 2h内及健康受试者血清 cTnⅠ、NSE及 S-100β水平，分析各检测指标与 ACOP程度、一氧化碳中毒后迟发性脑病( DEACMP)发生的相关性以及对 DEACMP的预测价值。结果 ACOP组病人血清 cTnⅠ［( 0.56±0.38)μg/L］、 NSE［(14.63±5.33)μg/L］及 S-100β［(0.21±0.18)μg/L］水平较健康对照组［(0.01±0.00)μg/L、(6.76±2.41)μg/L、(0.05±0.03)μg/L］明显升高，均差异有统计学意义( P<0.01)。 ACOP程度及 DEACMP发生均与血清 cTnⅠ、NSE及 S-100β水平呈显著正相关( P< |
| 英文摘要: |
| Objective To investigate the relationship between serum cardiac troponin I (cTnI), neuron-specific enolase (NSE) and central nervous system-specific protein (S-100β) and the degree of acute carbon monoxide poisoning (ACOP) and the predictive valueof delayed encephalopathy after carbon monoxide poisoning (DEACMP).Methods Sixty-eight ACOP patients admitted to the First Af filiated Hospital of Xinxiang Medical College from June 2017 to June 2019 were selected as the ACOP group, and 40 healthy subjectswho underwent physical examination in the hospital during this period were selected as the healthy control group. The serum levels ofcTnI, NSE and S-100β were detected and recorded in ACOP patients and healthy subjects within 2 hours of admission. The correlationof each index with the degree of ACOP, the occurrence of delayed encephalopathy after carbon monoxide poisoning (DEACMP) and thepredictive value of DEACMP were analyzed.Results The serum levels of cTnI [(0.56±0.38) μg/L], NSE [(14.63±5.33) μg/L] and S100β [(0.21±0.18) μg/L] in the ACOP group were significantly higher than those in the healthy control group [(0.01± 0.00) μg/L, (6.76±2.41) μg/L, (0.05±0.03) μg/L] (P < 0.01). The degree of ACOP and the occurrence of DEACMP were significantly positively correlated with serum cTnI, NSE and S-100β levels (P < 0.001). The incidence of DEACMP in ACOP patients was 27.94%. ROC curve analysisshowed that the sensitivity (0.947), specificity (0.878), Youden index (0.825) and area under the ROC curve (AUC=0.973) of serum S100β for the diagnosis of DEACMP were all significantly higher than cTnI (0.737, 0.694, 0.431, 0.787) and NSE (0.789, 0.694, 0.483,0.795), but the difference between the latter two was not statistically significant.Conclusions Serum cTnI, NSE and S-100β can re flect the degree of poisoning in ACOP patients and have a certain predictive effect on the occurrence of DEACMP, especially S-100β. The combined detection of cTnI, NSE and S-100β can further improve the predictive value of DEACMP and has important value inguiding the clinical diagnosis and early prevention of DEACMP. |
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