| 庄兰妹,陈海华,朱婷,等.慢性阻塞性肺疾病急性期血清白细胞介素 -6、白细胞介素 -13和白细胞介素 -17A水平与 GOLD分级的关系[J].安徽医药,2022,26(4):750-754. |
| 慢性阻塞性肺疾病急性期血清白细胞介素 -6、白细胞介素 -13和白细胞介素 -17A水平与 GOLD分级的关系 |
| Relationship between serum IL-6, IL-13 and IL-17a levels with GOLD grade in acute stage of chronic obstructive pulmonary disease |
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| DOI：10.3969/j.issn.1009-6469.2022.04.025 |
| 中文关键词: 肺疾病，慢性阻塞性 白细胞介素 -6 白细胞介素 -13 白细胞介素 17 GOLD分级 |
| 英文关键词: Pulmonary disease, chronic obstructive Interleukin 6 Interleukin 13 Interleukin-17 GOLD grade |
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| 中文摘要: |
| 目的通过检测慢性阻塞性肺疾病( COPD)急性加重期和稳定期前后血清白细胞介素 6(IL-6)、白细胞介素 13(IL-13)和白细胞介素 17A(IL-17A)的水平变化，探讨 IL-6、IL-13和 IL-17A在 COPD急性加重期中的作用。方法选取 2017年 1月至 2018年 6月上海市静安区市北医院呼吸内科收治的 COPD急性加重期病人 42例设为 COPD急性加重期组( AECOPD)经过抗感染及对症治疗后病情稳定的 COPD病人 42例设为 COPD稳定期组。收集各组血清并采用双抗体加心法( ELISA)检测，IL-6、 IL-13和 IL-17A，同时采集和检测各组血 C-反应蛋白( CRP)、降钙素原( PCT)、血沉、白细胞数、中性粒细胞及嗜酸性粒细胞数，采用肺功能评估 COPD稳定期的 COPD全球创议( GOLD)分级。结果 COPD稳定期和急性期之间的相关炎症指标 CRP、血沉(ESR)、 PCT、白细胞计数( WBC)、中性粒细胞计数( Neu)、 IL-6、IL-13和 IL-17A有差异有统计学意义( P<0.01)。 COPD急性期 CRP、ESR、PCT、白细胞计数、中性粒细胞计数、 IL-6、IL-13和 IL-17A均显著高于稳定期( P<0.05)。 COPD病人血清 IL-6、IL-13和 IL-17A水平治疗前后均差异有统计学意义( P<0.01)。急性期病人随着 GOLD分级的级别增高，血清 IL-13和 IL-17A是增高的， GOLD分级与血清 IL13呈正相关( r=0.58，P<0.01)与 IL-17A水平呈正相关( r=0.53，P<0.01)与 IL-6水平不相关( r=0.25，P= |
| 英文摘要: |
| Objective To discuss the role of serum IL-6, IL-13, and IL-17a levels in acute exacerbation of COPD by measuring the levels of serum IL-6, IL-13 and IL-17a during acute exacerbation and stabilization state.Methods Forty-two patients who were admit ted to the respiratory department of Shibei Hospital from January 2017 to June 2018 were selected as the AECOPD group. After anti-infection and symptomatic treatment, 42 patients were assigned to the stable COPD group. The serum of each group was collected todetect IL-6, IL-13, and IL-17a by double antibody cardioversion (ELISA), and the blood c-reactive protein (CRP), calcitonin (PCT),sedimentation, white blood cells, neutrophil and eosinophil Numbers were also collected and detected. Lung function was used to eval uate the GOLD classification of COPD in stable state.Results C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), PCT, white blood cell count (WBC), neutrophil count (Neu), IL-6, IL-13 and IL-17a were significantly different between stable COPD and acute COPD (P < 0.01). CRP, ESR, PCT, white blood cell count, neutrophil count, IL-6, IL-13 and IL-17a in acute phase of COPD were significantly higher than those in stable phase(P<0.05). The serum levels of IL-6, IL-13 and IL-17a in patients with COPD before and after treatment were significantly different (P < 0.01). The levels of serum IL-13 and IL-17a increased with the GOLD grading. Gold grade was positively correlated with serum IL-13 ( r = 0.58, P < 0.01) and IL-17a (r = 0.53, P < 0.01), but not with IL-6(r = 0.25, P = 0.114). The serum IL-17a level of patients in stable phase was significantly different from that of gold classification (P < 0.01), and was positively correlated with gold classification (r = 0. 566, P < 0.01).Conclusion IL-6, CRP, PCT, erythrocyte sedimen tation rate, white blood cell count, neutrophil count and so on are all increased in acute exacerbation of COPD but lack of specificityand correlation. The level of IL-13 is positively correlated with GOLD grade, while the level of IL-17a is correlated with airway inflam mation and remodeling in COPD. Combined detection of IL-6, IL-13 and IL-17a related cytokines can better guide the management and treatment of patients with COPD. |
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