| 袁小笋,张蕾,马慧利,等.长链非编码RNA HULC 在乳腺癌组织中表达及临床意义[J].安徽医药,2022,26(5):982-985. |
| 长链非编码RNA HULC 在乳腺癌组织中表达及临床意义 |
| Expression and clinical significance of long non-coding RNA HULC in breast cancer |
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| DOI：10.3969/j.issn.1009-6469.2022.05.031 |
| 中文关键词: 乳腺肿瘤 长链非编码RNA 肝癌高表达转录本 临床病理指标 预后 Cox比例风险回归模型 |
| 英文关键词: Breast neoplasms Long non-coding RNA HULC Clinicopathological indicators Prognosis Cox proportional haz?ards regression model |
| 基金项目:河南省科技发展计划(142102310459) |
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| 中文摘要: |
| 目的探讨长链非编码RNA肝癌高表达转录本(HULC)在乳腺癌组织中表达及临床意义。方法选取2013年5月至2015年5月在南阳市中心医院乳腺科行手术治疗且资料完整的乳腺癌病人112例，实时荧光定量PCR术检测乳腺癌和正常乳腺组织中HULC表达，病人均于术后1 d开始随访，随访截止日期2020年5月31日，以死亡作为终点事件，记录病人生存时间，采用Kaplan-Meier法进行生存分析，采用Cox比例风险回归模型分析影响乳腺癌病人预后的风险因素。结果乳腺癌组织中HULC表达量为(2.27±0.18)，高于正常乳腺组织的(1.02±0.08)，差异有统计意义(t=67.38，P<0.001)；不同组织学分级、TNM分期、淋巴结转移、ER和Ki-67的乳腺癌组织中HULC表达量差异有统计学意义(P<0.05)；以乳腺癌组织中HULC表达量的P25值为界值，将病人分为低表达组(n=29)和高表达组(n=83)，低表达组病人生存时间(52.72±3.06)个月，5年生存率为82.76%，高表达组病人则分别为(35.51±2.25)个月和36.14%，差异有统计学意义(χ2=15.16，P<0.001)；HULC表达是影响乳腺癌病人预后的独立风险因素［HR=5.249(95%CI:1.965～14.024)，P<0.05］。结论乳腺癌组织中HULC表达量升高，可能发挥类似癌基因的作用而参与了乳腺癌进展，且是影响病人预后的风险因素。 |
| 英文摘要: |
| Objective To investigate the expression and clinical significance of long non-coding RNA HULC in breast cancer.Meth?ods A total of 112 cases of patients with breast cancer who underwent surgical treatment with complete data in the Department of Mammary Gynecology, Nanyang Central Hospital from May 2013 to May 2015 were selected. Real-time quantitative PCR was used to detect the expression of HULC in breast cancer and normal breast tissues. All patients were followed up one day after the operation,and the deadline for follow-up was May 31, 2020, with death as the end event, and the survival time of patients was recorded. Kaplan-Meier method was used to survival analysis, and Cox proportional hazard regression model was used to analyze the risk factors affecting the prognosis of breast cancer patients.Results The expression level of HULC in breast cancer tissue was (2.27±0.18), which was higher than (1.02±0.08) in the normal breast tissue, the difference was statistically significant (t=67.38, P<0.001). The differences of the expression levels of HULC in breast cancer tissues with different histological grades, TNM stages, lymph node metastasis, ER and Ki-67 were statistically significant (P<0.05). Taking the P25 value of the expression level of HULC in breast cancer as the cut-off value,the patients were assigned into low expression group (n=29) and high expression group (n=83).The average survival time of patients and the 5-year survival rate in the low expression group were (52.72±3.06) months and 82.76%,respectively,while in the high expression group were (35.51±2.25) months and 36.14%, respectively, the difference was statistically significant (χ2=15.16,P<0.001). The expres?sion of HULC was risk factors that affect the prognosis of breast cancer patients [HR=5.249 (95%CI:1.965-14.024),P<0.05].Conclu?sion The expression of HULC in breast cancer tissues is increased, it may play an oncogene-like role and participate in breast cancer progression, and it is a risk factor that affects the prognosis of patients. |
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