| 王新征,侯永强,汲权威.血清长链非编码RNA-尿路上皮癌相关分子1对甲状腺乳头状癌的鉴别诊断价值[J].安徽医药,2022,26(5):1004-1007. |
| 血清长链非编码RNA-尿路上皮癌相关分子1对甲状腺乳头状癌的鉴别诊断价值 |
| Value of detection of LncRNA UCA1 in the differential diagnosis of thyroid nodules |
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| DOI：10.3969/j.issn.1009-6469.2022.05.036 |
| 中文关键词: 甲状腺肿瘤 甲状腺结节 癌，乳头状 血清 长链非编码RNA-尿路上皮癌相关分子1 诊断 |
| 英文关键词: Thyroid neoplasms Thyroid nodule Carcinoma,papillary Serum long non-coding RNA urothelial cancer related molecule 1 Diagnosis |
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| 摘要点击次数: 1016 |
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| 中文摘要: |
| 目的检测甲状腺良性结节和甲状腺乳头状癌病人血清长链非编码RNA-尿路上皮癌相关分子1(LncRNA UCA1)水平，并探讨其对甲状腺乳头状癌的鉴别诊断价值。方法选取2018年1月至2020年1月河南科技大学第一附属医院住院治疗的甲状腺乳头状癌病人48例(甲状腺乳头状癌组)和甲状腺良性结节病人32例(良性结节组)为研究对象(均为术后病理确诊)；同期选取甲状腺功能正常的49例健康体检人群为健康对照组。采用实时荧光定量PCR(qRT-PCR)法检测血清中Ln?cRNA UCA1水平；分析血清LncRNA UCA1表达水平与甲状腺乳头状癌病人临床病理特征的关系；采用受试者工作特性曲线(ROC曲线)分析血清中LncRNA UCA1水平对甲状腺结节良恶性的鉴别诊断价值。结果甲状腺乳头状癌组LncRNA UCA1水平(2.13±0.49)高于健康对照组(1.00±0.24)和良性结节组(1.48±0.30)，良性结节组LncRNA UCA1水平高于健康对照组，均差异有统计学意义(P<0.05)；LncRNA UCA1高表达组多发病灶、肿瘤大小>10 mm、有淋巴结转移、TNM分期为Ⅲ~Ⅳ期的病人比例高于LncRNA UCA1低表达组，差异有统计学意义(P<0.05)；血清LncRNA UCA1水平诊断甲状腺良性结节的曲线下面积(AUC)为0.899，截断值为1.194，特异度为81.6%，灵敏度为81.3%；血清LncRNA UCA1水平诊断甲状腺癌的AUC为0.891，截断值为1.837，特异性为96.9%，敏感度为77.1%。结论血清LncRNA UCA1水平可能对甲状腺乳头状癌有一定的鉴别诊断价值，同时能估计甲状腺乳头状癌病情的发展状况，可为甲状腺乳头状癌的早期干预提供一定的参考依据。 |
| 英文摘要: |
| Objective To detect the level of serum long non-coding RNA urothelial carcinoma associated molecule 1 (LncRNAUCA1) in patients with thyroid benign nodules and thyroid cancer, and to explore its value in the differential diagnosis of benign and malignant thyroid nodules.Methods Forty-eight patients with papillary thyroid cancer (papillary thyroid cancer group) and 32 pa?tients with benign thyroid nodules (benign nodule group) who were treated and hospitalized in the First Affiliated Hospital of Henan University of Science and Technology from January 2018 to January 2020 were selected as the research objects (All are pathologically diagnosed after surgery); at the same time, 49 healthy people with normal thyroid function were selected as the control group. The level of serum LncRNA UCA1 was detected by real-time fluorescent quantitative PCR (qRT-PCR); the relationship between the expression level of serum LncRNA UCA1 and the clinicopathological characteristics of papillary thyroid cancer patients was analyzed; and the val?ue of serum LncRNA UCA1 level in differential diagnosis of benign and malignant thyroid nodules was analyzed by receiver operating characteristic (ROC) curve.Results In the results of this study, the level of LncRNA UCA1 in papillary thyroid cancer group (2.13±0.49) was higher than that in control group (1.00±0.24) and benign nodule group (1.48±0.30), and the level of LncRNA UCA1 in benign nodule group was higher than that in normal control group, the differences were statistically significant (P<0.05); the proportions of pa?tients with multiple lesions, tumor size > 10 mm, lymph node metastasis TNM staging Ⅲ-Ⅳ in the LncRNA UCA1 high expression group was higher than that in the LncRNA UCA1 low expression group (P<0.05); the area under curve (AUC) of serum LncRNA UCA1 in the diagnosis of benign thyroid nodules was 0.899, the cutoff value was 1.194, the specificity was 81.6%, and the sensitivity was 81.3%; the AUC of serum lcrna UCA1 in the diagnosis of thyroid cancer was 0.891, the cutoff value was 1.837, the specificity was 96.9%, and the sensitivity was 77.1%.Conclusion The level of serum LncRNA UCA1 may have a certain value in the differential di?agnosis of benign and malignant thyroid nodules, and it can also estimate the development of papillary thyroid cancer, which can pro?vide some reference for the early intervention of papillary thyroid cancer. |
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