| 任晓娜,郑磊,杨静,等.微波消解 -电感耦合等离子体质谱法测定拉坦前列素中钯和铝[J].安徽医药,2022,26(6):1107-1110. |
| 微波消解 -电感耦合等离子体质谱法测定拉坦前列素中钯和铝 |
| Determination of palladium and aluminum in latanoprost using microwave digestion and ICP-MS |
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| DOI：10.3969/j.issn.1009-6469.2022.06.010 |
| 中文关键词: 电感耦合等离子体质谱法 微波消解 拉坦前列素 钯 铝 |
| 英文关键词: Inductive coupled plasma mass spectrometry ( ICP-MS) Microwave digestion Latanoprost Palladium Aluminum |
| 基金项目:中国药学会精准用药科技传播促进行动 2019年重点项目［ CMEI2019KPYJ(JZYY)00204］；山东省 2019—2020年度中医药科技发展计划项目( 20190329) |
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| 中文摘要: |
| 目的建立一种采用电感耦合等离子体质谱法( ICP-MS)测定拉坦前列素中残留的钯和铝元素的含量方法。方法该研究起止时间为 2020年 2—4月。拉坦前列素样品处理方法选择微波消解法，其中射频功率限定为 1 300 W，载气选择是氩气，流速设定为 15.0 L/min，雾化器气体流速设定为 0.9 L/min，雾化室温度为 4℃，采样深度为 8.0 mm，通过在线加入内标元素的方法来校正基质效应。结果钯和铝在 1~200 μg/L线性范围内线性关系良好，方法检测限分别为 4 μg/kg和 1 μg/kg。回收率验证中，钯元素为 97.3%［相对标准差( RSD)=1.4%］，铝元素为 97.9%(RSD=1.5%)。结论该研究建立的测定钯和铝元素残留的方法，具有操作简便、快捷、灵敏度高等优点，适用于拉坦前列素中钯和铝残留的检测。 |
| 英文摘要: |
| Objective To develop a method for the determination of palladium and aluminum residue in latanoprost using inductively coupled plasma mass spectrometry (ICP-MS).Methods The study started from February 2020 and ended in April 2020. The samples were digested using microwave digestion technology. The radio-frequency power was 1 300 W, argon was chosen as the carrier gasand the flow rate was set at 15.0 L/min. And the flow rate of atomizer gas was 0.9 L/min, the atomizing temperature was 4 ℃. and thesampling depth was 8.0 mm. The matrix effect was corrected via on-line addition of the internal standard elements.Results There was a good linear relationship within the range of 1-200 μg/L for palladium and aluminum. The limits of detection ( LOD) were 4 μg/kg forpalladium and 1 μg/kg for aluminum. The average recovery was 97.3% and relative standard deviation (RSD) was 1.4% for palladium,and the average recovery was 97.9% and RSD was 1.5% for aluminum.Conclusion The method was proved to be simple, rapid andsensitive, which was suitable for the determination of palladium and aluminum residue in latanoprost. |
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