| 刘文静,李元芹,嵇桂娟,等.血清总胆红素与支气管扩张症急性加重期严重程度的相关性分析[J].安徽医药,2022,26(6):1133-1136. |
| 血清总胆红素与支气管扩张症急性加重期严重程度的相关性分析 |
| Correlation analysis of serum bilirubin and severity of acute exacerbation of bronchiectasis |
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| DOI：10.3969/j.issn.1009-6469.2022.06.016 |
| 中文关键词: 支气管扩张症 胆红素 白细胞计数 C反应蛋白质 支气管扩张严重指数 |
| 英文关键词: Bronchiectasis Bilirubin Leukocyte count C-reactive protein Bronchiectasis severity index |
| 基金项目:江苏省“六大人才高峰”高层次人才项目( WSN-081) |
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| 中文摘要: |
| 目的探讨血清总胆红素水平与支气管扩张症急性加重期严重程度的相关性。方法回顾性收集 2017年 3月至 2020年 5月在徐州医科大学附属医院住院治疗的支气管扩张症病人 481例，纳入符合入组条件的 191例。收集入组病人血清总胆红素、改良英国 MRC呼吸困难指数( mMRC)评分和影像学肺叶受累及程度，用 Sperman相关性分析，分析总胆红素和 mMRC评分及肺叶受累及程度的相关性。根据支气管扩张严重指数( BSI)将入组的病人分为轻度组、中度组、重度组。用 Pearson相关性分析，分析白细胞、 C反应蛋白( CRP)、胆红素、 BSI评分之间的相关性。用多重线性回归分析法分析 BSI评分的影响因素。结果胆红素水平和 mMRC评分及肺叶受累及程度均呈负相关(P<0.05)。轻、中、重度组的 BSI评分分别为( 2.25± |
| 英文摘要: |
| Objective To investigate the relationship between serum bilirubin level and the severity of acute exacerbation of bronchiectasis.Methods The medical records of 481 patients with bronchiectasis admitted to the Affiliated Hospital of Xuzhou MedicalUniversity from March 2017 to May 2020 were retrospectively reviewed. According to inclusion and exclusion criteria, a total of 191 patients were included in this study. Total serum bilirubin levels, the Modified Medical Research Council (mMRC) Dyspnea Scale, andthe extent of lung involvement on chest CT were assessed. The correlations between total serum bilirubin, mMRC and CT images wereanalyzed by Spearman correlation. According to the severity index of bronchiectasis (BSI), the patients were divided into mild group,moderate group and severe group. The correlations between white blood cell (WBC) count, CRP, bilirubin, and BSI scores were analyzed by Pearson correlation. Factors associated with BSI score were analyzed by multivariate linear regression analysis.Results Serum bilirubin level was negatively correlated with mMRC score and number of lung lobes affected with bronchiectasis (P<0.05). BSIscores in mild, moderate and severe groups were (2.25±1.23), (6.13±1.12) and (11.77±2.45), respectively. The higher the severity ofbronchiectasis, the higher the BSI scores were. In patients with bronchiectasis, a gradual decline in serum bilirubin levels was determined from the mild to the severe group [mild group: (12.60±3.90) μmol/L; moderate group: (8.3±2.0) μmol/L; severe group: (7.48±2.78) μmol/L]. The leukocyte levels of the three groups were (6.36±2.77) 109/L, (7.85±2.70) 109/L and (8.76±3.87) 109/L, respectively (P<0.05). CRP levels were (8.56±3.23) mg/L, (36.55±6.64) mg/L, (52.81±6.46) mg/L (P<0.05), respectively. With the increase of bronchiectasis severity higher WBC count and CRP levels were observed. Serum bilirubin level was negatively correlated with BSI score,WBC and CRP (P<0.05). BSI level was positively correlated with WBC and CRP (P<0.05). Multiple linear regression analysis showed that WBC, CRP and serum bilirubin were all influencing factors of BSI (all P<0.05).Conclusion Serum bilirubin was negatively corre lated with the the severity of acute exacerbation of bronchiectasis and can predict the severity of bronchiectasis. |
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