| 张帅芝,郝翠芳,张慧敏,等.子宫内膜大细胞神经内分泌癌 1例[J].安徽医药,2022,26(6):1162-1166. |
| 子宫内膜大细胞神经内分泌癌 1例 |
| Large cell neuroendocrine carcinoma of endometrium: a case report |
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| DOI：10.3969/j.issn.1009-6469.2022.06.024 |
| 中文关键词: 子宫内膜肿瘤 癌，大细胞 癌，神经内分泌 治疗 预后 老年人 |
| 英文关键词: Endometrial neoplasms Carcinoma, large cell Carcinoma, neuroendocrine Treatment The prognosis Aged |
| 基金项目: |
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| 中文摘要: |
| 目的探讨子宫内膜大细胞神经内分泌癌( large cell neuroendocrine carcinoma，LCNEC)的临床特点、病理特点、诊疗经过及预后情况。方法回顾 1例烟台毓璜顶医院(第一作者住院医师规范化培训单位) 2017年 5月妇科收治的子宫内膜大细胞癌病人的临床表现、病理、治疗及预后。结果女， 69岁，因绝经 13年，不规则阴道流血 2个月，以“子宫内膜癌”收入院。该病人接受了腹腔镜筋膜外子宫切除 +双侧附件切除 +淋巴结清扫术，术后病理提示“子宫内膜大细胞神经内分泌癌”，术后进行了 6个周期的化疗(依托泊苷 +顺铂)和 30次放疗，术后随访至 2020年 8月 6日已生存了 39个月。结论子宫内膜 LCNEC具有极强的侵袭性，临床表现无特异性，通过手术以及术后辅以放化疗等综合治疗，可以取得良好的预后。 |
| 英文摘要: |
| Objective To investigate the clinical features, diagnosis, treatment and prognosis of endometrial large cell neuroendocrine carcinoma (LCNEC).Methods The clinical manifestation, treatment and prognosis of a patient with large cell carcinoma of endometrium treated in the Department of Gynecology of Yuhuangding Hospital of Yantai (the first author's standardized training unit forresidents) in May 2017 were reviewed.Results A 69-year-old female was admitted to the hospital with "endometrial cancer" becauseof 13 years of menopause and irregular vaginal bleeding for 2 months. The patient underwent laparoscopic extrafascial hysterectomyand bilateral adnexal resection and lymph node dissection. Postoperative pathology revealed "endometrial large cell neuroendocrinecarcinoma". Six cycles of chemotherapy (etoposide and cisplatin) and 30 radiotherapy were performed after operation, and 39 months ofsurvival had been achieved by postoperative follow-up up to August 6, 2020.Conclusions Endometrial large cell neuroendocrine carcinoma is highly invasive and has no specific clinical manifestations. A good prognosis can be obtained by surgery and postoperative radiotherapy and chemotherapy. |
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