| 李晶晶.针刺疗法联合左西替利嗪治疗老年皮肤瘙痒 49例疗效[J].安徽医药,2022,26(6):1214-1217. |
| 针刺疗法联合左西替利嗪治疗老年皮肤瘙痒 49例疗效 |
| Effect of acupuncture combined with levocetirizine in the treatment of 49 cases of senile pruritus |
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| DOI：10.3969/j.issn.1009-6469.2022.06.037 |
| 中文关键词: 瘙痒症 针刺疗法 左西替利嗪 血清炎性因子 老年人 |
| 英文关键词: Pruritus Acupuncture therapy Levocetirizine Serum inflammatory factors Aged |
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| 中文摘要: |
| 目的研究针刺疗法联合左西替利嗪治疗老年皮肤瘙痒的疗效。方法选取就诊于商丘市中医院 2018年 11月至 2019年 11月的 98例老年皮肤瘙痒病人，采用随机数字表法将其分为对照组和观察组，每组 49例。对照组采用左西替利嗪治疗，观察组采用针刺疗法联合左西替利嗪治疗。治疗 20 d后，观察两组病人的治疗效果、治疗前后中医证候积分、白细胞介素 1β(IL-1β)、白细胞介素 -2(IL-2)、肿瘤坏死因子 -α(TNF-α)水平、皮肤瘙痒时间、发生频率、程度评分、治疗总满意率及复发率。结果观察组的治疗总有效率( 89.80%)高于对照组( 73.47%)(P<0.05)；治疗前两组中医证候积分差异无统计学意义( P>0.05)，治疗后对照组［(21.37±3.81)分比( 43.12±7.31)分］、观察组［(15.13±4.36)分比( 44.07±6.74)分］中医证候积分均降低( P<0.05)，且观察组变化幅度大于对照组(P<0.05)；治疗前两组 IL-1β、IL-2及 TNF-α水平比较差异无统计学意义( P>0.05)治疗后对照组、观察组 IL-1β［(36.27±1.34)μg/L、(21.46±1.23)μg/L比( 45.59±1.78)μg/L、(46.21±1.58)μg/L］、 IL-2［(19.21±2.89g/L)μ，(12.57±2.13)μg/L比( 23.64±3.46)μg/L、(24.11±3.24)μg/L］、 TNF-α水平［(13.42±2.16)μg/L、(8.20±2.11)μg/L比(15.67±2.10)μg/ L、(15.34±2.04)μg/L］均降低，且观察组降低趋势高于对照组( P<0.05)；治疗前两组皮肤瘙痒时间、发生频率、程度评分比较差异无统计学意义(P>0.05)，治疗后两组皮肤瘙痒时间、发生频率、程度评分均降低，且观察组降低趋势更明显( P<0.05)；观察组治疗总满意率高于对照组( P<0.05)；观察组的复发率低于对照组( P<0.05)。结论针刺疗法联合左西替利嗪治疗老年皮肤瘙痒效果显著，可降低炎性因子水平，改善瘙痒症状，值得临床医师推广。 |
| 英文摘要: |
| Objective To study the curative effect of acupuncture combined with levocetirizine in the treatment of senile pruritus. Methods From November 2018 to November 2019, ninety-eight senile patients with pruritus in Shangqiu Hospital of Traditional Chinese Medicine were selected and assigned into control group and observation group according to the random number table method, with49 cases in each group. The control group was treated with levocetirizine, while the observation group was treated with acupuncturecombined with levocetirizine. The treatment effect, TCM syndrome scores before and after treatment, levels of interleukin-1β (IL-1β), interleukin-2 (IL-2) and tumor necrosis factor-α (TNF-α), average skin itching time, occurrence frequency, degree score, total satisfaction rate and recurrence rate of the two groups were observed.Results The total effective rate of the observation group (89.80%) was higher than that of the control group (73.47%) (P < 0.05). Before treatment, there was no significant difference in TCM syndrome scores between the two groups (P > 0.05); after treatment, TCM syndrome scores of the control group [(21.37±3.81) vs. (43.12±7.31)] and the observation group [(15.13±4.36) vs. (44.07±6.74)] were both decreased, and the decrease trend of the observation group was more obvious (P < 0.05). Before treatment, the levels of IL-1β, IL-2 and TNF-α had no significant difference between the two groups (P > 0.05); after treatment, the levels of IL-1β [(36.27±1.34) μg/L, (21.46±1.23) μg/L vs. (45.59±1.78) μg/L, (46.21±1.58) μg/L], IL-2 [(19.21± 2.89) μg/L, (12.57±2.13) μg/L vs. (23.64±3.46) μg/L, (24.11±3.24) μg/L] and TNF-α [(13.42±2.16) μg/L, (8.20±2.11) μg/L vs. (15.67±2.10) μg/L, (15.34±2.04) μg/L] in the control group and the observation group were both decreased, and the decrease trend in the observation group was more obvious (P < 0.05). Before treatment, there were no significant differences in the average itching time, occurrence frequency and degree score between the two groups (P > 0.05); after treatment, the average itching time, occurrence frequencyand degree score of the two groups both decreased, and the decrease trend of the observation group was more obvious (P < 0.05). The total satisfaction rate of the observation group was higher than that of the control group (P < 0.05), and the recurrence rate of the observation group was lower than that of the control group (P < 0.05).Conclusions Acupuncture combined with levocetirizine in the treat ment of senile pruritus has a significant effect. It can reduce the level of inflammatory factors and improve the symptoms of pruritus, |
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