| Objective To explore and analyze the characteristics and regularity of the ADR induced by linagliptin, and to providereference for rational drug use in clinical practice.Methods Data of CNKI, Wanfang database, CQVIP, and PubMed databases fromMay 2011 to December 2020 were retrieved for ADR induced by linagliptin,and literature were collected for further statistical analysis.Results Fifteen literature were selected, including 16 patients, which contained 11 males and 5 females. Most of them (12 cases,75.00%) were elderly (≥ 60 years old), with an mean age of (67.94±11.66) years old. Most ADR (15 cases,93.75%) occurred within 6months, and 1 case occurred 56 months after medication. ADR involved skin system (11 cases), digestive system (4 cases) and urinarysystem (1 case), including bullous pemphigoid (BP) 9 (68.75%) cases, maculopapular drug eruption 1 (6.25%) case, acute pancreatitis 2(12.50%) cases, liver injury 2 (12.50%) cases, and acute kidney injury 1 (6.25%) case. After drug withdrawal and corresponding treatment, 16 patients were all improved or recovered.Conclusion We should be alert to the medication risk of linagliptin, strengthen thesafety monitoring, identify and handle ADR as early as possible, and ensure the medication safety for patients. |
