| Objective To observe the effect of Shenfu injection (SFI) improves prognosis and clinical indicators of septic shock pa-tients.Methods The clinical data of 147 patients with septic shock who were met the criteria in the Department of Intensive CareUnit, the Fifth Affiliated Hospital of Zhengzhou University from January 2018 to December 2019 were retrospectively analyzed. Accord-ing to SFI treatment, patients were assigned into SFI group (n=67) and non-SFI group (n=80). Gender, age, heart rate, left ventricular ejection fraction (LVEF), B-type natriuretic peptide (BNP), mean arterial pressure (MAP), dose of norepinephrine (NE), lactate levels,SOFA score, total bilirubin (TBIL), creatinine (Cr), platelet (PLT), site of infection causing septic shock, ICU stay time and prognosiswere retrospectively collected.Results There were no differences in all the baseline data between SFI group and non-SFI group (P > 0.05). LVEF, BNP, dose of norepinephrine, lactate levels, SOFA score in the SFI group and the non-SFI group on day 6 of diagnosis ofseptic shock [(57.9 ± 6.3)%, (54.7 ± 6.2)%, 109.0 (74.0, 217.0) ng/L, 147.5 (101.3, 327.0) ng/L, 0.10 (0.04, 0.20) μg·kg-1·min-1, 0.30 (0.17, 0.39)μg·kg-1 ·min-1, (1.66 ± 1.53) mmol/L, (2.41 ± 1.46) mmol/L, 7.0 (5.0, 9.0) score, 8.0 (6.0, 10.0) score] were lower than thoseon day 1 [(45.2 ± 6.7)%, (44.1 ± 7.6)%, 459.0 (294.0,935.0) ng/L, 502.0 (224.5,863.8) ng/L, 0.60 (0.40, 0.80) μg·kg-1·min-1, 0.55 (0.45, 0.70) μg·kg-1·min-1, (4.12 ± 1.89) mmol/L, (4.31 ± 1.44) mmol/L, 10.0 (8.0, 13.0) score, 10.0 (8.3, 12.0) score] (P < 0.05), and the indi-cators in SFI group was better than those in non-SFI group [(57.9 ± 6.3)% vs. (54.7 ± 6.2)%, 109.0 (74.0, 217.0)ng/L vs. 147.5 (101.3, 327.0) ng/L, 0.10 (0.04, 0.20)μg·kg-1·min-1 vs. 0.30 (0.17, 0.39)μg·kg-1·min-1, (1.66 ± 1.53)mmol/L vs. (2.41 ± 1.46) mmol/L, 7.0 (5.0, 9.0)score vs. 8.0 (6.0, 10.0) score] (P < 0.05). ICU stay time in SFI group was shorter than that in non-SFI group [(12.8 ± 5.1)day vs. |
