| 陈小霞,谢环,李晓兰.微小RNA-9 在子宫内膜癌组织中表达及意义[J].安徽医药,2022,26(8):1537-1540. |
| 微小RNA-9 在子宫内膜癌组织中表达及意义 |
| Expression of miR-9 in endometrial carcinoma and its significance |
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| DOI：10.3969/j.issn.1009-6469.2022.08.012 |
| 中文关键词: 子宫内膜肿瘤 微小RNA-9 临床病理指标 预后 Cox比例风险回归模型 |
| 英文关键词: Endometrial neoplasms miRNA-9 Clinicopathological parameters Prognosis Cox proportional hazards regres?sion model |
| 基金项目:湖北省自然科学基金(2015CFB574) |
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| 中文摘要: |
| 目的探讨微小RNA-9(miR-9)在子宫内膜癌组织中表达及意义。方法选取2012年4月至2014年4月在三峡大学宜宜昌市第二人民医院行手术治疗的子宫内膜癌病人97例，同期，留取因子宫良性病变行子宫切除手术的正常子宫内膜组织46份，实时荧光定量PCR术检测组织中miR-9表达，病人随访2～84个月，采用Kaplan-Meier法和Cox比例风险回归模型分析影响病人预后因素。结果子宫内膜癌组织中miR-9相对表达量高于正常子宫内膜组织［(0.25±0.10)比(1.02±0.14)，t=38.42，P<0.001］；相比于FIGO分期Ⅰ~Ⅱ期、组织学分级G1～G2期、浸润深度<1/2肌层、未淋巴结转移，miR-9相对表达量在Ⅲ~Ⅳ期［(0.20±0.09)比(0.28±0.10)］、G3期［(0.20±0.08)比(0.28±0.10)］、≥1/2肌层［(0.21±0.09)比(0.28±0.10)］、淋巴结转移［(0.20±0.08)比(0.27±0.10)］显著降低(P<0.05)；相比于高表达组，miR-9低表达组生存时间［(34.82±5.96)个月比(69.23±3.12)个月］和累积生存率(24.00%比75.00%)均降低(χ2=28.37，P<0.001)；miR-9低表达是病人预后的风险因素(HR=0.305，P<0.05)。结论miR-9在子宫内膜癌组织中呈低表达，与代表病人恶性进展指标负相关。 |
| 英文摘要: |
| Objective To investigate the expression and significance of miR-9 in endometrial carcinoma.Methods A total of 97 cases of patients with endometrial carcinoma who underwent surgery in Yichang Second People's Hospital Affiliated to China Three Gorges University from April 2012 to April 2014 were selected. In the same period, 46 cases of normal endometrial tissues from benign lesions undergoing hysterectomy were collected. Real-time quantitative PCR was used to detect the expressions of miR-9 in tissues.The patients were followed up for 2 to 84 months, and Kaplan-Meier method and Cox proportional hazards regression model were used to analyze the prognostic factors of patients.Results The relative expression level of miR-9 in endometrial carcinoma tissue was high?er than that in the normal endometrial tissue [(0.25±0.10) vs. (1.02±0.14), t=38.42, P<0.001]. Compared with FIGO stage Ⅰ to Ⅱ stage, histological grade G1 to G2, invasion depth <1/2 muscle layer, and no lymph node metastasis, the relative expression levels of miR-9 in Ⅲ to Ⅳ stage [(0.20±0.09) vs. ( 0.28±0.10)], G3 stage [(0.20±0.08) vs. (0.28±0.10)], ≥1/2 muscle layer [(0.21±0.09) vs. (0.28±0.10)], lymph node metastasis [(0.20±0.08) vs. (0.27±0.10)] were significantly decreased (P<0.05). Compared with the high expression group, the survival time [(34.82±5.96) months vs. (69.23±3.12) months] and cumulative survival rate (24.00% vs. 75.00%) in the miR-9 low expression group were decreased (χ2=28.37, P<0.001). The low expression of miR-9 was a risk factor for patient prognosis (HR=0.305, P<0.05).Conclusion miR-9 is lowly expressed in endometrial carcinoma tissues, and negatively correlated with indicators rep?resenting the malignant progression of patients. |
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