| 朱琳玲,杜姝,梁娟,等.血清外异蛋白A 与糖尿病视网膜病变的相关性研究[J].安徽医药,2022,26(9):1756-1760. |
| 血清外异蛋白A 与糖尿病视网膜病变的相关性研究 |
| Correlation between serum levels of ectodysplasin A and diabetic retinopathy |
| |
| DOI：10.3969/j.issn.1009-6469.2022.09.014 |
| 中文关键词: 糖尿病视网膜病变 外异蛋白A 肝脏因子 倾向性评分匹配 |
| 英文关键词: Diabetic retinopathy Ectodysplasin A Hepatokine Propensity score matching |
| 基金项目:江苏省自然科学基金青年项目(BK20200209)；苏州市科教兴卫青年项目(KJXW2021051)；苏州市护理学会科研项目(SZHL-A-202209) |
|
| 摘要点击次数: 1023 |
| 全文下载次数: 327 |
| 中文摘要: |
| 目的探讨血清外异蛋白A在糖尿病视网膜病变(DR)中的表达水平及相关性。方法纳入2018年1月至2020年6月期间苏州大学附属理想眼科医院收治的50例非增生型糖尿病视网膜病变(NPDR)病人及50例增生型糖尿病视网膜病变(PDR)病人。另外，基于倾向性评分匹配原则纳入同一期间于该院行白内障治疗的50例单纯2型糖尿病无DR(NDR)病人以及50例健康体检者。使用酶联免疫吸附测定(ELISA)试剂盒检测各组血清外异蛋白A水平。统计方法包括二分类logistic回归，多变量线性回归及双变量偏相关性分析。结果DR 病人血清外异蛋白A 水平(365.40±56.51)ng/L 高于未患DR 组(294.40±54.00)ng/L，PDR病人的血清外异蛋白A水平(403.40±37.79)ng/L高于NDR组(301.80±60.31)ng/L和NPDR组(327.40±45.53)ng/L(均P<0.05)。200例参与者根据血清外异蛋白A水平四分位法平均分为Q1、Q2、Q3、Q4四组，随着血清外异蛋白A水平升高，DR发病频率越高［Q1~Q4:12%(6/50)，40%(20/50)，68%(34/50)，80%(40/50)，P<0.05］。做年龄、性别校正后，血清外异蛋白A水平与体质量指数(BMI)、腰臀比、收缩压、糖尿病病程、空腹血糖、空腹胰岛素(FINS)、糖化血红蛋白(HbA1c)、稳态模型胰岛素抵抗指数(HOMA-IR)、谷丙转氨酶(GPT)及谷草转氨酶(GOT)呈正相关；与体力活动及高密度脂蛋白胆固醇(HDL-C)呈负相关。均有P<0.05。预测外异蛋白A血清水平的最佳线性模型包含:DR疾病进展、空腹血糖、GOT、HDL-C及体力活动等。经校正后，血清外异蛋白A水平与DR发病风险显著关联，OR=1.016，P<0.05。亦与PDR发病风险显著关联，OR=1.073，P<0.05。结论血清外异蛋白A是DR发病的独立危险因素。 |
| 英文摘要: |
| Objective To evaluate the serum levels and and relevance of ectodysplasin A (EDA) in patients with diabetic retinopathy(DR).Methods Fifty patients with proliferative diabetic retinopathy (PDR), and 50 patients with non-proliferative diabetic retinopathy(NPDR) who were admitted to the Lixiang Eye Hospital Affiliated to Soochow University from January 2018 to June 2020 were included in this study. Besides, 50 diabetic mellitus patients with non-diabetic retinopathy (NDR) and 50 healthy controls who underwent cataract treatment at the same hospital during the same period were also included based on propensity score matching. Serum levels of EDA were measured by enzyme-linked immunosorbent assay (ELISA). Statistical methods included binary logistic regression, multivariate linear regression, and bivariate partial correlation analysis.Results The serum levels of EDA in DR patients [(365.40±56.51) ng/L] were higher than it in the subjects without DR [(294.40±54.00) ng/L] (P<0.05). Furthermore, the levels of EDA in PDR patients[(403.40±37.79) ng/L] was higher than that in NDR patients [(301.80±60.31) ng/L] (P<0.05) and NPDR patients [(327.40±45.53) ng/L](P<0.05). According to the quartile method of serum EDA levels, 200 participants were assigned into four groups: Q1, Q2, Q3 and Q4.With the increase of serum EDA levels, the frequency of DR increased [Q1-Q4: 12% (6/50), 40% (20/50), 68% (34/50) and 80% (40/50), P<0.05]. After the adjustment of age and sex, serum levels of EDA positively correlated with body mass index (BMI), waist-to-hip ratio (WHR), systolic blood pressure (SBP), diabetic mellitus course, fasting blood glucose (FPG), fasting insulin (FINS), glycosylated hemoglobin (HbA1c), steady-state model insulin resistance index (HOMA-IR), alanine aminotransferase (GPT) and aspartamine trans1aminases (GOT), while negatively with physical activity and high-density lipoprotein cholesterol (HDL-C) (all P<0.05). The best linear models for predicting serum EDA levels include DR disease progression, FPG, GOT, HDL-C and physical activity. After adjustment, serum EDA levels were significantly associated with the risk of DR (OR=1.016, P<0.05) and PDR (OR=1.073, P<0.05).Conclusion Serum EDA is an independent risk factor of DR. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
