| 金德斌,杨艳,张伯阳,等.继发性甲状旁腺功能亢进症行甲状旁腺全切手术前后心理状况评估[J].安徽医药,2022,26(9):1850-1853. |
| 继发性甲状旁腺功能亢进症行甲状旁腺全切手术前后心理状况评估 |
| Evaluation of psychological status before and after total parathyroidectomy for secondary hyperparathyroidism |
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| DOI：10.3969/j.issn.1009-6469.2022.09.036 |
| 中文关键词: 甲状旁腺切除术 甲状旁腺功能亢进症，继发性 心理健康 |
| 英文关键词: Parathyroidectomy Hyperparathyroidism, secondary Mental health |
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| 中文摘要: |
| 目的观察甲状旁腺全切术对继发性甲状旁腺功能亢进症(SHPT)病人伴发焦虑、抑郁的治疗效果。方法选取2018年1月至2019年7月秦皇岛市第一医院行甲状旁腺全切术的31例SHPT病人，分别于术前、术后1周及术后6个月，在病人自愿情况下行汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)、Pasieka甲状旁腺症状量表(PAS)评估，比较手术前后评分的变化。并同时监测血钙、血磷、钙磷乘积、全段甲状旁腺激素(iPTH)水平变化。结果HAMA评分术前、术后1周、术后6个月分别为(16.93±0.78)分、(8.97±0.61)分、(5.94±0.60)分(P<0.05)，HAMD评分术前、术后1周、术后6个月分别为(16.90±0.92)分、(14.68±0.83)分、(12.68±0.79)分(P<0.05)；PAS各症状评分均差异有统计学意义(P<0.05)，其中骨痛评分术前、术后1周、术后6个月分别为(42.62±5.24)分、(37.43±4.46)分、(36.11±4.45)分(P<0.05)；血清学指标中PTH术前、术后1周、术后6个月分别为(1 632.6±119.92)ng/L、(37.43±4.46)ng/L、(36.11±4.45)ng/L，术后与术前比较均差异有统计学意义(P<0.05)，而术后1周与术后6个月相比无明显变化，与其他血清学指标结果一致。结论甲状旁腺全切术是治疗SHPT的有效手段，手术后病人焦虑情况明显改善甚至消失，抑郁情绪、临床症状及血清学指标均有明显改善，术后6个月随访发现病人焦虑、抑郁、临床症状均较术后1周改善，且血清学指标稳定。 |
| 英文摘要: |
| Objective To observe the therapeutic effect of total parathyroidectomy on anxiety and depression in patients with secondary hyperparathyroidism (SHPT).Methods A total of 31 patients performing total parathyroidectomy in the First Hospital of Qinhuangdao from January 2018 to July 2019 were selected and voluntarily assessed with Hamilton Anxiety Scale (HAMA),Hamilton Depression Scale (HAMD)and parathyroid assessment of symptoms score(PAS)before operation, one week after operation and half a year after operation. Changes in score before and after operation were collected and compared. Serum levels of calcium, phosphorus, calcium-phosphorus product and parathyroid hormone (iPTH) were measured.Results HAMA scores before operation, one week after operation and half a year after operation were [(16.93±0.78), (8.97±0.61), (5.94±0.60)] (P<0.05).HAMD scores were [(16.90±0.92), (14.68±0.83), (12.68±0.79)] (P<0.05);There were significant differences in the PAS symptom scores (P<0.05). The bone pain scores were(42.62±5.24), (37.43±4.46), and (36.11±4.45) before operation, one week after operation and half a year after operation, respectively(P<0.05);PTH scores in Serological indicators were [(1 632.6±119.92) ng/L, (37.43±4.46) ng/L, (36.11±4.45) ng/L] before, one week after and half a year after operation, respectively.There were statistically significant differences between postoperative and preoperative results (P<0.05), and there was no significant change between one week after operation and half a year after operation, which was consistent with the results of other serological indicators.Conclusions Total parathyroidectomy is an effective channel in the treatment of SHPT.The anxieties of patients after operation are significantly improved and some are even diminished. Meanwhile,the depressive emotions,clinical symptoms and serological indexes are also improved significantly.Half a year after the operation, the follow-up showed that the anxiety,depression and clinical symptoms of the patients were improved, and the serological indexes were stable. |
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