| 李小勇,郭琴,郭海志.可溶性低密度脂蛋白受体相关蛋白 1在阿尔茨海默病血清中的表达及临床意义[J].安徽医药,2022,26(11):2249-2252. |
| 可溶性低密度脂蛋白受体相关蛋白 1在阿尔茨海默病血清中的表达及临床意义 |
| Expression change and clinical significance of soluble low-density lipoprotein receptor-related protein 1 in patients with Alzheimer's disease |
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| DOI：10.3969/j.issn.1009-6469.2022.11.029 |
| 中文关键词: 阿尔茨海默病 可溶性低密度脂蛋白受体相关蛋白 1 表达 临床意义 |
| 英文关键词: Alzheimer's disease Soluble low-density lipoprotein receptor-related protein 1 Expression Clinical significance |
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| 中文摘要: |
| 目的通过检测阿尔茨海默病( AD)病人血清中可溶性低密度脂蛋白受体相关蛋白 1(sLRP-1)的表达水平，分析其与 AD病人临床指标之间的关系，解析其在 AD诊断中的临床意义。方法选择 2016年 7月至 2020年 2月在资阳市第一人民医院确诊的 AD病人 82例为 AD组，同时选择在资阳市第一人民医院进行体检的健康者 95例为对照组，采用酶联免疫吸附实验(ELISA)法对所有受试者血清中 sLRP-1、β淀粉样蛋白 1-42(Amyloid-beta 1-42，Aβ1-42)水平进行测定、用全自动生化分析仪对血清中总胆固醇( TC)、三酰甘油( TG)、高密度脂蛋白胆固醇( HDL-C)、低密度脂蛋白胆固醇( LDL-C)含量进行测定，分析 AD病人血清中 sLRP-1表达水平与临床病理各项指标的相关性，受试者操作特征曲线(ROC)分析血清 sLRP-1表达水平对 AD的诊断价值。结果 AD病人 ADAS-cog评分高于对照组［( 18.90±5.06)分比( 5.52±2.38)分， P<0.05］，血清中 HDL-C水平［( 1.27± 0.29)mmol/L比( 1.43±0.22)mmol/L］、 ADL评分［( 70.92±23.13)分比( 98.87±23.73)分］、 MMSE评分［(24.03±5.17)分比( 28.73±7.37)分］均低于对照组( P<0.05)； AD组病人血清 sLRP-1表达水平显著低于对照组［(11.16±3.63)mg/L比( 17.84±5.31)mg/L，P< |
| 英文摘要: |
| Objective To detect the expression level of soluble low-density lipoprotein receptor-related protein 1 (sLRP-1) in serum of patients with Alzheimer's disease (AD), analyze the relationship between sLRP-1 and clinical indicators of AD patients, and analyze its clinical significance in the diagnosis of AD.Methods Eighty-two cases of AD patients diagnosed in Ziyang First People's Hospitalfrom July 2016 to February 2020 were selected as AD group, and 95 healthy people who had physical examination in Ziyang First Peo.ple's Hospital were selected as control group. The levels of serum sLRP-1 and amyloid β1-42 (Aβ1-42) were measured by enzyme-linked immunosorbent assay (ELISA), the contents of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) in serum were determined by automatic biochemical analyzer, the correlation be. tween sLRP-1 expression and clinicopathological parameters was analyzed, and receiver operating characteristic curve (ROC) was usedto analyze the diagnostic value of serum sLRP-1 in AD.Results The ADAS-cog score of AD patients was higher than that of the con. trol group [(18.90±5.06) vs. (5.52±2.38), P<0.05], and the serum HDL-C level [(1.27±0.29) mmol/L vs. (1.43±0.22) mmol/L], ADL score [(70.92±23.13) vs. (98.87±23.73)] and MMSE score [(24.03±5.17) vs. (28.73±7.37)] were lower than those of the control group (P<0.05); the expression level of serum sLRP-1 in AD group was significantly lower than that in control group [(11.16±3.63)mg/L vs. (17.84±5.31) mg/L, P<0.05], and serum Aβ1-42 concentration was significantly higher than that in control group [(53.34±16.07) μg/L vs. (38.31± 10.77) μg/L], with the deepening of dementia, the expression level of sLRP-1 in serum of AD patients decreased in turn (P<0.05), and the concentration of serum Aβ1-42 increased in turn (P<0.05); Pearson correlation analysis showed that the expression level of sLRP-1 was negatively correlated with Aβ1-42 concentration and ADAS-cog score (P<0.05), but positively correlated with HDL-C level, ADL score and MMSE score (P<0.05); ROC curve showed that the area under curve (AUC) of serum sLRP-1 in the diagnosis of AD was 0.84, 95% CI (0.77,0.90), sensitivity was 82.1%, specificity was 84.1%, cut-off value was 13.943 mg/L.Conclusion The change of serum sLRP-1 expression level is closely related to AD. ROC curve analysis shows that serum sLRP-1 expression level has certain diagnostic value for AD. |
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