| 黄友光.皮肤鳞状细胞癌 73例血清膜联蛋白 A2的表达水平及与预后的关系[J].安徽医药,2022,26(12):2452-2455. |
| 皮肤鳞状细胞癌 73例血清膜联蛋白 A2的表达水平及与预后的关系 |
| Expression of serum annexin A2 in patients with cutaneous squamous cell carcinoma and its relationship with prognosis |
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| DOI：10.3969/j.issn.1009-6469.2022.12.026 |
| 中文关键词: 皮肤肿瘤 癌，鳞状细胞 膜联蛋白 A2 血清 预后 |
| 英文关键词: Skin neoplasms Carcinoma, squamous cell Annexin A2 Serum Prognosis |
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| 中文摘要: |
| 目的探究皮肤鳞状细胞癌( CSCC)病人血清膜联蛋白 A2的表达水平及与预后的关系。方法回顾性分析 2011年 10月至 2014年 3月济宁市皮肤病防治院收治的 CSCC病人 73例为( CSCC组)研究对象，根据随访结果分为预后良好组( n=54)和预后不良组( n=19)，另取同期门诊健康体检者血清标本 80例为对照组，采用酶联免疫吸附测定( ELISA)检测血清膜联蛋白 A2水平， Cox分析影响 CSCC病人不良结局的危险因素。结果 CSCC病人血清膜联蛋白 A2(64.78±6.23)μg/L水平显著高于对照组( 16.45±5.64)μg/L(P<0.05)。血清膜联蛋白 A2水平与 CSCC病人年龄、性别、发病部位、原发灶相比差异无统计学意义( P>0.05)与淋巴结转移、分化程度、侵犯深度有关( P<0.05)。预后不良组 CSCC病人血清膜联蛋白 A2(69.67±10.62)μg/L水平显著高于预，后良好组( 60.09±10.25)μg/L(P<0.05)。 Cox多因素分析发现，淋巴结转移、侵犯深度及血清膜联蛋白 A2水平高是影响 CSCC病人预后的独立危险因素［ HR=2.547、2.726、3.520；95%CI:(1.518，3.274)、(2.035，3.652)、(1.701，7.284)，均 P< |
| 英文摘要: |
| Objective To investigate the relationship between the expression of Annexin A2 in serum and prognosis of patients withcutaneous squamous cell carcinoma (CSCC).Methods A retrospective analysis was conducted. A total of 73 CSCC patients admittedto Jining Dermatology Hospital from October 2011 to March 2014 were selected as the research object (CSCC group). According to thefollow-up results, the patients were divided into good prognosis group (n=54) and poor prognosis group (n=19). Another 80 serum sam.ples from healthy outpatients at the same time were taken as the control group.The serum Annexin A2 level was detected by enzyme-linked immunosorbent assay (ELISA), and Cox was used to analyze the risk factors of adverse outcomes in CSCC patients.Results The serum Annexin A2 (64.78±6.23) μg/L level of CSCC patients was significantly higher than that of the control group (16.45±5.64) μg/L(P<0.05). Serum Annexin A2 level was not related to age, gender, disease site and primary tumor of CSCC patients (P>0.5), but was re. lated to lymph node metastasis, degree of differentiation and depth of invasion (P<0.05). The serum Annexin A2 (69.67±10.62) μg/L level in CSCC patients in poor prognosis group was significantly higher than that in the good prognosis group (60.09±10.25) μg/L (P< 0.05). Cox multivariate analysis showed that lymph node metastasis, depth of invasion and high serum Annexin A2 level were indepen.dent risk factors for the prognosis of CSCC patients [HR= 2.547, 2.726, 3.520;95%CI:(1.518, 3.274), (2.035, 3.652), (1.701, 7.284), all P<0.001].Conclusions The up-regulated expression of serum Annexin A2 level may be related to lymph node metastasis, degree ofdifferentiation and depth of invasion in CSCC patients. It is speculated that Annexin A2 is a risk factor affecting the poor prognosis ofCSCC patients. |
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