| 洪丽明,田秘,李乐辉,等.重症肺炎支原体肺炎老年人血清纤维蛋白原、血小板反应蛋白 -1表达及其与预后的相关性[J].安徽医药,2022,26(12):2466-2469. |
| 重症肺炎支原体肺炎老年人血清纤维蛋白原、血小板反应蛋白 -1表达及其与预后的相关性 |
| The expression of FIB and TSP-1 in elderly patients with severe mycoplasma pneumoniae pneumonia and their correlation with prognosis |
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| DOI：10.3969/j.issn.1009-6469.2022.12.029 |
| 中文关键词: 肺炎，支原体 纤维蛋白原 血小板反应蛋白 -1 预后 老年人 |
| 英文关键词: Pneumonia, mycoplasma Fibrinogen Thrombospondin-1 Prognosis Aged |
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| 中文摘要: |
| 目的检测重症肺炎支原体肺炎( MPP)病人血清纤维蛋白原( FIB)和血小板反应蛋白 -1(TSP-1)的表达情况，并探究其表达水平与 MPP病人预后的相关性。方法选取 2017年 3月至 2018年 12月在海南医学院第一附属医院收治的 MPP老年人 89例作为研究对象，其中重症 MPP 46例作为重症组，轻症 MPP 43例作为对照组。采用酶联免疫吸附测定( ELISA)检测各组研究对象血清 FIB、TSP-1的表达水平；通过受试者操作特征曲线( ROC曲线)评估血清 FIB、TSP-1表达水平对重症 MPP的诊断价值；分析病人预后不良情况发生率；并采用 logistic回归分析老年人发生预后不良的相关影响因素。结果重症组血清 FIB、TSP-1表达水平分别为( 4.93±1.16)g/L、(375.42±34.13)μg/L，显著高于对照组的( 3.85±0.97)g/L、(316.71±23.05)μg/L(P<0.05)。ROC结果显示，血清 FIB和 TSP-1单独及联合诊断重症 MPP的曲线下面积(AUC)分别为 0.796、0.900、0.926，血清 FIB联合 TSP-1诊断重症 MPP的灵敏度和特异度分别为 84.82%、90.65%。高 FIB组、高 TSP-1组老年人病人预后不良发生率分别为54.55%(12/22)、 55.00%(11/20)，显著高于低 FIB组的 16.67%(4/24)及低 TSP-1组的 19.23%(5/26)(P<0.05)。 logistic回归分析显示，血清 FIB、TSP-1表达水平是影响重症 MPP病人发生预后不良的独立危险因素(均 P<0.05)。结论 FIB和 TSP-1在重症 MPP病人血清中的表达水平明显升高，且其高表达与病人预后不良有关，均可作为重症 MPP的早期诊断及预后评估的潜在生物学指标。 |
| 英文摘要: |
| Objective To detect the expression of serum fibrinogen (FIB) and thrombospondin-1 (TSP-1) in patients with severe My.coplasma pneumoniae pneumonia (MPP) and to explore the correlation between their expression level and the prognosis of MPP pa.tients.Methods A total of 89 cases of elderly MPP patients admitted to the First Affiliated Hospital of Hainan Medical College fromMarch 2017 to December 2018 were selected as study subjects, including 46 cases of severe MPP as the severe group and 43 cases ofmild MPP as the control group. Enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of serum FIB and TSP-1 in each group; the receiver operating characteristic (ROC) curve was used to assess the diagnostic values of serum FIB and TSP-1 expres.sion levels in severe MPP; the incidence of poor prognosis in patients was analyzed; and logistic regression was used to analyze the in.fluencing factors related to the occurrence of poor prognosis in elderly individuals.Results The expression levels of serum FIB and TSP-1 in the severe group were (4.93±1.16) g/L and (375.42±34.13) μg/L, respectively, which were significantly higher than those inthe control group [(3.85±0.97) g/L and (316.71±23.05) μg/L] (P<0.05). ROC results showed that the area under the curve (AUC) of se. rum FIB and TSP-1 alone and in combination were 0.796, 0.900 and 0.926, respectively, and the sensitivity and specificity of serumFIB in combination with TSP-1 for the diagnosis of severe MPP were 84.82% and 90.65%, respectively. The incidence of poor progno.sis in elderly patients in the high FIB group and high TSP-1 group was 54.55% (12/22) and 55.00% (11/20), respectively, which wassignificantly higher than those in the low FIB group [16.67% (4/24)] and the low TSP-1 group [19.23% (5/26)] (P<0.05). Logistic regres. sion analysis showed that the levels of serum FIB and TSP-1 were independent risk factors for the development of poor prognosis in se. vere MPP patients (P<0.05).Conclusion The expression levels of FIB and TSP-1 in the serum of severe MPP patients were signifi.cantly elevated, and their high expression was associated with poor patient prognosis, both of which can be used as potential biologicalindicators for the early diagnosis and prognostic assessment of severe MPP. |
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