| 王安安,李文娟,黄文琦,等.清灵方联合盐酸多奈哌齐治疗卒中后认知功能障碍的临床研究[J].安徽医药,2022,26(12):2524-2528. |
| 清灵方联合盐酸多奈哌齐治疗卒中后认知功能障碍的临床研究 |
| Clinical Research of Qingling granule combined with donepezil hydrochloride in the treatment of cognitive dysfunction after stroke |
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| DOI：10.3969/j.issn.1009-6469.2022.12.042 |
| 中文关键词: 卒中 国立神经系统疾病与卒中研究所(美国) 认知功能障碍 清灵方 盐酸多奈哌齐 临床疗效 |
| 英文关键词: Stroke National institute of neurological disorders and stroke Cognitive dysfunction Qingling granule Donepezil hydrochloride Clinical efficacy |
| 基金项目:上海市静安区卫生科研课题( 2019ZY03)；静安区中医药临床重点专科建设项目( JA2020-Z008) |
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| 中文摘要: |
| 目的观察清灵方联合盐酸多奈哌齐治疗卒中后认知功能障碍的临床疗效。方法选取上海市静安区中医医院 2019年 7月至 2021年 7月收治卒中后认知功能障碍者 82例，采用随机数字表法将病人分为对照组和治疗组，每组各 41例。其中对照组除了基础治疗外给予盐酸多奈哌齐片(每片 5 mg)口服，每日 1次，每次 1片；治疗组在对照组基础上联合清灵方治疗，将一日量的清灵方(颗粒剂) 51 g，加开水至 200 mL冲化温服，分早晚两次服用。两组均连续治疗 3个月。比较两组治疗前后简易精神状态量表( MMSE)、蒙特利尔认知评估量表( MoCA)、美国国立卫生研究院卒中量表( NIHSS)、日常生活活动能力(ADL)、血清神经元特异性烯醇化酶( NSE)、同型半胱氨酸( HCY)变化，统计两组临床治疗总有效率，并记录两组治疗期间不良反应情况。结果治疗后，两组 MoCA积分［对照组( 17.56±2.59)分、治疗组( 21.57±3.28)分］两组 MMSE积分［对照组(18.31±3.91)分、治疗组(23.27±4.34)分］较治疗前两组 MoCA积分［对照组( 15.48±3.01)分、治疗组(15.，96±3.41分)］和 MMSE积分［对照组( 16.78±5.53)分、治疗组( 16.78±5.53)分)均有增高( P<0.05)且治疗组优于对照组( P<0.05)。治疗后，两组 ADL积分、 NIHSS积分均较治疗前有所改善( P<0.05)，治疗组优于对照组( P<0.05，)。治疗后，对照组总有效率 73.17%(30/41)，治疗组总有效率 90.24%(37/41)，两组差异有统计有意义(P<0.05)。治疗后，两组 NSE、HCY水平均低于治疗前，且治疗组优于对照组 |
| 英文摘要: |
| Objective To investigate clinical effect of Qingling granule combined with donepezil hydrochloride in the treatment of cognitive dysfunction after stroke.Methods Eighty-two patients with cognitive dysfunction after stroke with sputum and blood stasiswere randomized into the control group and the observation group, with forty-one cases in each group. The patients in the control groupwere treated with donepezil hydrochloride on the basis of conventional treatment for three months and the patients in the observationwere also treated with Qingling granule that 51 g added into 200ml water in the morning and evenig per day and donepezil hydrochlo.ride on the basis of conventional treatment for three months. The changes of Mini-Mental State Examination(MMSE), Montreal Cogni.tive Assessment (MoCA), NIH Stroke Scale (NIHSS), activities of daily living (ADL), neuron-specific enolase (NSE), homocysteine(Hcy) were observed before and after treatment. We also had a comprehensive statistics of the total effective rates of the control groupand the observation group and recorded the adverse reaction.Results After treatment, the MoCA scores of the two groups were 17.56±2.59 and 21.57±3.28 and the MMSE scores of the two groups were 18.31±3.91 and 23.27±4.34 respectively, which were increased thanthose before treatment that the MoCA scores of the two groups were 15.48±3.01 and 15.96±3.41 and the MMSE scores of the two groupswere 16.53±3.94 and 16.78±5.53 (P<0.05) and those in the observation group were better than those in the control group (P<0.05). ADL scores and NIHSS scores were also improved (P<0.05); The total effective rate of the observation group 90.24%(37/41) was signifi.cantly higher than that of the control group 73.17%(30/41) (P<0.05). The factor of NSE and HCY after treatment both decreased than before and the difference was statistically significant (P<0.05). The adverse reactions of the two groups were not statistically different (P>0.05).Conclusion Qingling granule combined with donepezil hydrochloride in the treatment of cognitive dysfunction could relievethe clinical symptoms of cognitive dysfunction after stroke, improve neurological and cognitive function, regulate the factor level of NSEand HCY and crowned with high security. |
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