| 达梦婷,陈道桢,杨蕊,等.藤黄酸在乳腺癌治疗中的研究进展[J].安徽医药,2024,28(1):1-5. |
| 藤黄酸在乳腺癌治疗中的研究进展 |
| Advances in the study of gambogic acid in the treatment of breast cancer |
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| DOI：10.3969/j.issn.1009-6469.2024.01.001 |
| 中文关键词: 藤黄属 乳腺癌 抗肿瘤作用 纳米制剂 药物载体 综述 |
| 英文关键词: Garcinia Breast cancer Anti-tumour effects Nano-formulation Drug carriers Review |
| 基金项目:青海省自然科学基金面上项目( 2022-ZJ-912) |
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| 摘要点击次数: 500 |
| 全文下载次数: 165 |
| 中文摘要: |
| 藤黄酸作为中药藤黄的主要生物活性成分，通过多种机制发挥抗肿瘤作用，包括诱导细胞凋亡、抑制肿瘤血管的生成和转移以及逆转肿瘤的多药耐药等；尤其是在乳腺癌治疗中可发挥多种抗肿瘤作用，有望成为乳腺癌的治疗药物。但藤黄酸自身存在缺陷，如水溶性差、半衰期短等，限制其临床应用。随着纳米载药制剂的不断发展，有望改善藤黄酸的不足，发挥藤黄酸强大的抗肿瘤作用。因此，综述近五年藤黄酸治疗乳腺癌的相关文献，以期为最大化藤黄酸抗乳腺癌奠定基础。 |
| 英文摘要: |
| Gambogic acid, as the main bioactive component of gambogic, exerts anti-tumor effects through various mechanisms, in-cluding induction of apoptosis, inhibition of tumor angiogenesis and metastasis, and reversal of tumor multidrug resistance. In particu-lar, it can exert a variety of anti-tumour effects in the treatment of breast cancer and is expected to become a breast cancer treatmentdrug. However, gambogic has its own defects, such as poor water solubility and short half-life, which limit its clinical application. With the continuous development of nano-loaded drug formulations, it is expected to improve the shortcomings of gambogic acid and bring in- to play its powerful anti-tumour effects. Therefore, we reviewed the literature related to gambogic acid in breast cancer treatment in thepast five years, in order to lay the foundation for maximizing gambogic acid against breast cancer. |
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