| 舒新乐,侯亚儒,张莹.高血压合并焦虑病人血清微 RNA-451a、胰岛素样生长因子 -1受体表达水平与焦虑程度的关系[J].安徽医药,2024,28(1):53-57. |
| 高血压合并焦虑病人血清微 RNA-451a、胰岛素样生长因子 -1受体表达水平与焦虑程度的关系 |
| Relationship between serum microRNA-451a and insulin-like growth factor-1 receptor expression levels and anxiety degree in patients with hypertension complicated with anxiety |
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| DOI：10.3969/j.issn.1009-6469.2024.01.012 |
| 中文关键词: 高血压 焦虑 微 RNA-451a 胰岛素样生长因子 -1受体( IGF1R) 影响因素分析 |
| 英文关键词: Hypertension Anxiety MicroRNA-451a Insulin-like growth factor-1 receptor (IGF1R) Influence factor analysis |
| 基金项目:国家自然科学基金委员会资助项目( 81770345) |
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| 中文摘要: |
| 目的探讨高血压合并焦虑病人血清微 RNA-451a(miR-451a)、胰岛素样生长因子 -1受体(IGF1R)表达水平与焦虑程度的关系。方法选取 2020年 2月至 2022年 1月在汉中市中心医院进行治疗的高血压病人 160例，根据临床诊断和汉密尔顿焦虑量表( HAMA)评估将病人分为高血压组 60例、高血压合并轻度焦虑情绪组 48例、高血压合并中度焦虑情绪组 32例和高血压合并重度焦虑情绪组 20例，收集整理所有病例的临床基础资料。采用实时荧光定量 PCR法检测血清 miR-451a表达水平、 ELISA法检测血清 IGF1R表达水平；比较分析高血压病人和高血压合并焦虑情绪病人的临床病理特征；采用 Pearson法分析 HAMA评分与血清 miR-451a、IGF1R表达水平的相关性；采用 logistic回归分析高血压合并焦虑的影响因素。结果高血压组、轻度焦虑、中度焦虑和重度焦虑组病人血清 miR-451a水平依次降低( 0.88±0.30，0.59±0.14，0.48±0.11，0.38±0.09)IGF1R水平依次升高［(2.14±0.60)μg/L，(2.66±0.62)μg/L，(3.08±0.66)μg/L，(3.51±0.74)μg/L］；血清 miR-451a水平与 HAMA评分，呈负相关(r=-0.50，P<0.05)，血清 IGF1R水平与 HAMA评分呈正相关( r=0.43，P<0.05)；高血压合并焦虑组收缩压［( 142.26±18.51) mmHg，(135.29±17.84)mmHg］、舒张压［( 84.25±11.30)mmHg，(78.23±10.25)mmHg］、 C-反应蛋白［( 4.47±0.96)mg/L，(4.16± 0.91)mg/L］IL-6水平［(36.95±6.31)μg/L，(27.48±5.49)μg/L］显著高于高血压组， IL-10水平［(12.34±3.26)ng/L，(16.24±3.91)ng/ L］显著低于高、血压组( P<0.05)；多因素 logistic回归分析结果显示，收缩压［ OR 95%CI=1.33(1.06，1.67)］、舒张压［ OR 95%CI= 1.20(1.00，1.45)］、 IL-6［OR 95%CI=1.89(1.22，2.93)］、 IL-10［OR 95%CI=0.38(0.17，2.93)］、 miR-451a［OR 95%CI=0.01(0.00， |
| 英文摘要: |
| Objective To investigate the relationship between serum microRNA-451a (miR-451a), insulin-like growth factor-1 recep- tor (IGF1R) and anxiety degree in patients with hypertension complicated with anxiety.Methods A total of 160 hypertension patientswho underwent treatment in Hanzhong Central Hospital from February 2020 to January 2022 were selected, and the patients were divid-ed into 60 cases in the hypertension group, 48 cases in the hypertension complicated with mild anxiety disorder group, 32 cases in thehypertension complicated with moderate anxiety disorder group, and 20 cases in the hypertension complicated with severe anxiety disor-der group according to the clinical diagnosis and the assessment of the Hamilton Anxiety Scale (HAMA). The basic clinical data of allcases were collected and organized. The expression level of serum miR-451a was detected by real-time fluorescent quantitative PCR,and the expression level of serum IGF1R was detected by ELISA. To compare the clinicopathologic characteristics of hypertensive pa-tients and patients with hypertension complicated with anxiety. The Pearson method was used to analyze the correlation between HA-MA score and serum miR-451a and IGF1R expression levels. Logistic regression was used to analyze the influencing factors of hyper- tension with anxiety.Results Serum miR-451a levels were sequentially decreased (0.88±0.30, 0.59±0.14, 0.48±0.11, 0.38±0.09) andIGF1R levels were sequentially increased [(2.14±0.60) μg/L, (2.66±0.62) μg/L, (3.08±0.66) μg/L, (3.51±0.74) μg/L] in patients fromthe hypertensive group, the mildly anxious, moderately anxious, and severely anxious groups. The serum miR-451a level was negatively correlated with the HAMA score (r= - 0.50, P<0.05), and the serum IGF1R level was positively correlated with the HAMA score (r= 0.43, P < 0.05). In the hypertension combined with anxiety group, the systolic blood pressure [(142.26±18.51) mmHg, (135.29±17.84)mmHg], diastolic blood pressure [(84.25±11.30) mmHg, (78.23±10.25) mmHg], C-reactive protein [(4.47±0.96) mg/L, (4.16±0.91) mg/ L ], and IL-6 levels [(36.95±6.31) μg/L, (27.48±5.49) μg/L] were significantly higher than those in the hypertensive group, and IL-10 levels [(12.34±3.26) ng/L, (16.24±3.91) ng/L] were significantly lower than those in the hypertensive group (P<0.05). The multivariate logistic regression analysis showed that systolic blood pressure [OR 95%CI=1.33 (1.06, 1.67)], diastolic blood pressure [OR 95%CI=1.20 (1.00, 1.45)], IL-6[OR 95%CI=1.89 (1.22, 2.93)], IL-10 [OR 95%CI=0.38 (0.17, 2.93)], miR-451a [OR 95%CI=0.01 (0.00, 0.47)], and IGF1R [OR 95%CI=7.62 (1.21,48.03)] levels were the influencing factors of hypertension combined with anxiety (P<0.05).Conclu- sion The low expression of miR-451a and high expression of IGF1R in the serum of patients with hypertension combined with anxietywere closely related to the degree of anxiety. |
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