| 任卫宁,王立波,刘翠珠,等.肛瘘术后病人血清钙结合蛋白 S100A8、促红细胞生成素表达与创面愈合、肛门功能的关系[J].安徽医药,2024,28(2):317-321. |
| 肛瘘术后病人血清钙结合蛋白 S100A8、促红细胞生成素表达与创面愈合、肛门功能的关系 |
| Relationship between serum S100A8, EPO expression and wound healing and anal function in patients with anal fistula |
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| DOI：10.3969/j.issn.1009-6469.2024.02.023 |
| 中文关键词: 直肠瘘 钙结合蛋白 S100A8 促红细胞生成素 创面愈合 肛门功能 |
| 英文关键词: Rectal fistula Calcium-binding protein S100A8 Erythropoietin Wound healing Anal function |
| 基金项目:河北省中医药管理局中医药科研计划项目( 2022399) |
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| 中文摘要: |
| 目的探究肛瘘术后病人血清钙结合蛋白 S100A8(S100A8)、促红细胞生成素( EPO)表达与创面愈合、肛门功能的关系。方法以 2020年 5月至 2022年 3月河北中医学院第二附属医院收治的 96例肛瘘病人为研究对象，所有病人均接受肛瘘手术治疗。对比治疗前后病人血清 S100A8、EPO水平及肛门失禁 Wexner评分，比较不同血清 S100A8、EPO水平病人疗效、创面愈合时间、 14 d创面愈合率及 Wexner评分； Pearson相关性分析血清 S100A8、EPO与创面愈合时间、 14 d创面愈合率及 Wexner评分的相关性；多因素 logistic回归分析肛瘘术效果的影响因素。结果术后，病人血清 S100A8较术前明显降低［( 65.34±6.21)μg/L比( 83.15±8.92)μg/L，P<0.05］，EPO水平较术前明显升高［( 52.36±5.67)U/L比( 33.67±4.86)U/L，P<0.05］， Wexner评分较术前明显降低［(9.74±2.22)分比( 21.02±5.31)分， P<0.05］。术后血清 S100A8低表达者较高表达者疗效更优( P<0.05)EPO高表达者较低表达者疗效更优( P<0.05)。术后血清 S100A8高表达者较低表达者创面愈合时间更长( P<0.05)，14 d创面率更低( P<0.05)Wexner评分更高( P<0.05)血清 S100A8与创面愈合时间呈正相关，与创面愈合率呈负相关)。术后血清 EPO高者较低表达者创面愈合时间更短( P<0.05)，14 d创面愈合率更高( P<0.05)Wexner评分呈正相关(均P<0.05)Wexner评分更低( P<0.05)血清 EPO与创面愈合时间呈负相关，与创面愈合率呈正相关，与 Wexner评分呈负相关(均 P<0.05)。多因素 logistic回归分析100A8高表达、 EPO低表达是影响肛瘘术后效果的危险因素。结论肛瘘术后病人血清 S100A8、EPO与病人创面愈合时间、 14 d创面愈合率、 Wexner评分显著相关，能够反应病人创面愈合及肛门功能情况。 |
| 英文摘要: |
| Objective To explore the relationship between the expressions of serum calcium-binding protein S100A8 (S100A8) and erythropoietin (EPO) and wound healing and anal function in patients with anal fistula.Methods A total of 96 patients with anal fistu.la admitted to the Second Affiliated Hospital of Hebei University of traditional Chinese medicine from May 2020 to March 2022 wereselected as the research objects. All patients received surgical treatment of anal fistula. The levels of serum S100A8 and EPO and theWexner score of anal incontinence were compared before and after treatment, the curative effect, wound healing time, 14-day woundhealing rate and Wexner score of patients with different serum S100A8 and EPO levels were compared; the correlation between serumS100A8, EPO and wound healing time, 14-day wound healing rate and Wexner score was analyzed by Pearson correlation analysis. Mul.tivariate logistic regression analysis was applied to analyze the influencing factors of anal fistulasurgery.Results After operation, the serum S100A8 of the patients was significantly lower than that before operation[(65.34±6.21)μg/L vs. (83.15±8.92)μg/L,P<0.05], the level of EPO was significantly higher than that before operation[(52.36±5.67)U/L vs. (33.67±4.86)U/L,P<0.05], and the Wexner score was significantly lower than that before operation[(9.74±2.22) vs. (21.02±5.31),P<0.05]. Patients with low expression of serum S100A8 had better curative effect than those with high expression after operation (P<0.05), and those with high expression of EPO had better cu. rative effect than those with low expression (P<0.05). After operation, those with high expression of serum S100A8 had longer wound healing time (P<0.05), lower 14-day wound healing rate (P<0.05), and higher Wexner score than those with low expression (P<0.05). Se.rum S100A8 was positively correlated with wound healing time, negatively correlated with wound healing rate, and positively correlatedwith Wexner score (all P<0.05). Those with high expression of serum EPO had shorter wound healing time (P<0.05), higher 14-day wound healing rate (P<0.05), and lower Wexner score than those with low expression (P<0.05). Serum EPO was negatively correlatedwith wound healing time, positively correlated with wound healing rate, and negatively correlated with Wexner score (all P<0.05). Multi.variate logistic regression analysis showed that high expression of S100A8 and low expression of EPO were risk factors affecting the out.come of anal fistula surgery.Conclusion Serum S100A8 and EPO in patients with anal fistula are significantly correlated with wound healing time, 14-day wound healing rate and Wexner score, which can reflect the wound healing and anal function of patients. |
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