| 魏子洋,周清清,邢滔,等.薄层电子计算机断层扫描 +纹理技术联合微 RNA-25对纯磨玻璃结节浸润性的诊断价值[J].安徽医药,2024,28(2):326-330. |
| 薄层电子计算机断层扫描 +纹理技术联合微 RNA-25对纯磨玻璃结节浸润性的诊断价值 |
| Guidance value of thin-layer CT+texture technique combined with miR-25 to evaluate infiltrative pure ground glass nodules |
| |
| DOI：10.3969/j.issn.1009-6469.2024.02.025 |
| 中文关键词: 结节病，肺 磨玻璃影 薄层电子计算机断层扫描 纹理技术 纯磨玻璃结节 浸润性 |
| 英文关键词: Sarcoidosis, pulmonary Ground-glass opacity Thin-layer CT Texture technique Pure ground glass nodules Infiltration |
| 基金项目:南京市医药卫生科研课题( YKK20192)；南京医科大学附属江宁医院青年创新科研重点项目( JNYYZXKY202022) |
|
| 摘要点击次数: 358 |
| 全文下载次数: 164 |
| 中文摘要: |
| 目的探讨薄层电子计算机断层扫描( CT)+纹理技术联合微 RNA-25(miR-25)对纯磨玻璃结节( pGGN)浸润性的诊断价值。方法选取 2019年 1月至 2021年 11月南京医科大学附属江宁医院 pGGN病人 115例，根据病理检查结果分为浸润前组、浸润性组，比较两组薄层 CT征象与参数、纹理特征参数、 miR-25，对数据进行统计处理。结果浸润性组圆度［( 62.51±8.29)%］低于浸润前组［(78.64±10.03)%］平均 CT值( .462.33±41.80)高于浸润前组( .462.33±41.80)(P<0.05)；浸润性组表面积、最大有效长径、质量、体积、逆差距为( 91.56±25.37)mm2(10.37±2.40)mm、(246.15±72.35)mg、(620.49±155.84)mm2分别，(0.09±0.03)，浸润前组表面积、最大有效长径、质量、体积、逆差别为( 62.42±18.49)mm2(8.43±1.25)mm、(130.58±41.86mg、(338.52±102.39)mm2、(0.15±0.05)，两组以上参数比较，均差异有统计学意义( P<0.05)；性组 miR-25(1.69±0.34)高于浸润前组( 1.18±0.27)(P<0.05)；圆度、平均 CT值、表面积、最大有效长径、质量、体积、逆差距均与 pGGN浸润性独立相关( P< 距分、)、浸润、0.05)；评估 pGGN浸润性的 AUC:圆度为 0.81，平均 CT值为 0.80，表面积为 0.71，最大有效长径为 0.75，质量为 0.81，体积为 0.80，逆差距为 0.72，各参数联合为 0.89。结论薄层 CT+纹理技术联合 miR-25均与 pGGN浸润性相关，联合应用可显著提高对 pGGN浸润性的鉴别诊断价值，或可成为评估 pGGN浸润性的一种无创、可靠方案，为临床治疗提供重要参考信息。 |
| 英文摘要: |
| Objective To investigate the value of thin-layer electron computed tomography (CT) + texture technique combined with microRNA-25 (miR-25) to evaluate the infiltrative nature of pure ground glass nodules (pGGN). Methods 115 patients with pGGNfrom January 2019 to November 2021 in Jiangning Hospital Affiliated to Nanjing Medical University were selected and divided into pre-infiltrative and infiltrative groups according to the pathological examination, and the data were statistically processed by comparing thethin-layer CT signs and parameters, texture feature parameters, and miR-25 between the two groups.Results The roundness [(62.51± 8.29)%] was lower in the infiltrative group [(78.64±10.03)%] than in the pre-infiltration group, and the mean CT value (.462.33±41.80) was higher than that of the pre-infiltration group (.462.33±41.80) (P<0.05); the surface area, maximum effective length diameter, mass,volume, and inverse gap in the infiltrative group were (91.56± (25.37) mm2, (10.37±2.40) mm, (246.15±72.35) mg, (620.49±155.84) mm2, (0.09±0.03), respectively, in the infiltrative group, and (62.42±18.49) mm2, (8.43±1.25) mm, (8.43±1.25) mm, respectively, in the pre-infiltrative group for surface area, maximum effective length, mass, volume, and inverse gap,(130.58±41.86) mg, (338.52±102.39) mm2,(0.15±0.05),and the above parameters were statistically significant between the two groups (P<0.05); miR-25 was higher in the in. filtrative group (1.69±0.34) than in the pre-infiltrative group (1.18±0.27) (P<0.05); roundness, mean CT value, surface area, maximumeffective length diameter, mass, volume, and inverse gap were independently correlated with pGGN infiltration (P<0.05); AUC for as.sessing pGGN infiltration: roundness was 0.81, mean CT value was 0.80, surface area was 0.71, maximum effective length diameter was0.75, mass was 0.81, volume was 0.80, inverse gap was 0.72, and each parameters jointly was 0.89.Conclusion Thin layer CT+tex. ture technique combined with miR-25 are both associated with pGGN infiltration, and the combined application can significantly im.prove the differential diagnostic value of pGGN infiltration, which may become a non-invasive and reliable protocol for assessing pGGN infiltration and provide important reference information for clinical treatment. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
