| 郑焱华,卢俊会,陈星.非酒精性脂肪肝病和心力衰竭:临床证据和病理生理学机制[J].安徽医药,2024,28(3):451-456. |
| 非酒精性脂肪肝病和心力衰竭:临床证据和病理生理学机制 |
| Non-alcoholic fatty liver disease and heart failure: clinical evidence and pathophysiological mechanisms |
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| DOI：10.3969/j.issn.1009-6469.2024.03.006 |
| 中文关键词: 非酒精性脂肪性肝病 心力衰竭 心血管疾病 病理生理学 治疗 |
| 英文关键词: Nonalcoholic fatty liver disease Heart failure Cardiovascular disease Pathophysiology Treatment |
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| 中文摘要: |
| 非酒精性脂肪性肝病( NAFLD)和心力衰竭(心衰)是两大重要的公共健康问题。 NAFLD增加心血管疾病(冠状动脉疾病、心房颤动、高血压、心肌病、心衰)风险间接或直接与心衰关联。 NAFLD通过胰岛素抵抗、肾素 -血管紧张素 -醛固酮系统和交感神经系统的激活、全身炎症、氧化应激、肠道菌群失调和扩张的异位脂肪等病理生理学机制促进心脏重塑和心衰的发生和进展。该研究总结了 NAFLD与心衰关联的临床证据和病理生理学机制，及这两种疾病可能的管理和治疗。 |
| 英文摘要: |
| Non-alcoholic fatty liver disease (NAFLD) and heart failure are two important public health problems. The increased risk ofcardiovascular diseases (coronary heart disease, atrial fibrillation, hypertension, cardiomyopathy, heart failure) in NAFLD is indirectlyor directly associated with heart failure. NAFLD accelerates cardiac remodeling and the development and progression of heart failurethrough the pathophysiological mechanisms of insulin resistance, activation of the renin-angiotensin-aldosterone system and sympathet.ic nervous system, systemic inflammation, oxidative stress, gut microbiota dysbiosis and expanded adipose tissue. This review summa.rizes the clinical evidence and pathophysiological mechanisms of the association of NAFLD with heart failure, as well as possible man.agement strategies for two diseases. |
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