| 杨文珍,王小龙,罗程,等.帕金森病病人静息状态下大脑四维时空一致性的变化研究[J].安徽医药,2024,28(3):512-516. |
| 帕金森病病人静息状态下大脑四维时空一致性的变化研究 |
| Study on the changes of four-dimensional spatio-temporal consistency of brain in patients with Parkinson's disease at rest |
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| DOI：10.3969/j.issn.1009-6469.2024.03.018 |
| 中文关键词: 帕金森病 磁共振成像 局部神经活动四维(时空)一致性 诊断效能 辅助运动区 |
| 英文关键词: Parkinson's disease Magnetic resonance imaging tivities Diagnostic efficiency Supplementary motor area |
| 基金项目:海南省临床医学中心建设项目(琼卫医函〔2021〕276号) |
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| 中文摘要: |
| 目的探索帕金森病( PD)病人静息状态下大脑四维时空一致性的变化研究。方法对 2021年 6月至 2022年 1月在海南医学院第一附属医院就诊的 31例 PD病人( PD组)和该院同期招募的 42例健康人群［健康对照组( HC组)］进行静息态功能磁共振( rs-fMRI)检查，运用 dapabi进行图像处理，计算出各组的局部神经活动四维(时空)一致性( FOCA)数值，并进行两独立样本 t检验，提取差异有统计学意义的脑区，采用受试者操作特征曲线( ROC曲线)分析各异常脑区 FOCA值对 PD的诊断效能。结果与 HC组比较， PD组 FOCA增高的脑区有左侧小脑后叶 Ⅷ区， FOCA值减低的脑区有右侧辅助运动区； ROC曲线结果显示， FOCA的曲线下面积是 0.846。结论 PD病人脑功能活动改变可能与疾病的临床症状有关， FOCA值可能对 PD有潜在的辅助诊断价值。 |
| 英文摘要: |
| Objective To explore the changes of four-dimensional spatial-temporal consistency in the resting state of Parkinson's dis. ease (PD).Methods Thirty-one patients with PD (PD group) and 42 healthy controls (HC group) were examined by Resting state func.tional magnetic resonance (fMRI) in the First Affiliated Hospital of Hainan Medical College from June 2021 to January 2022. Dapabiwas used for image processing, and the four-dimensional (spatio-temporal) consistency of local neural activities (FOCA) values of eachgroup were calculated. The brain regions with statistical differences were extracted by two samples t-test. Receiver operating character.istic (ROC) curve was used to analyze the diagnostic efficiency of FOCA values of abnormal brain regions in PD.Results Comparedwith HC group, the area of left posterior cerebellar lobe Ⅷ with increased FOCA and the right auxiliary motor area with decreased FO.CA in PD group; ROC curve showed that the area under the curve of FOCA was 0.846.Conclusion The changes of brain function inpatients with PD may be related to the clinical symptoms of the disease, and the value of FOCA may have potential diagnostic value forPD. |
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