| 刘玉杰,赵志强,王子琤.血清乳脂肪球表皮生长因子 8、鸢尾素对结直肠息肉病人复发的预测价值[J].安徽医药,2024,28(3):530-533. |
| 血清乳脂肪球表皮生长因子 8、鸢尾素对结直肠息肉病人复发的预测价值 |
| Predictive value of serum MFG-E8 and irisin for recurrence in patients with colorectal polyps |
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| DOI：10.3969/j.issn.1009-6469.2024.03.022 |
| 中文关键词: 结直肠息肉 乳脂肪球表皮生长因子 8 鸢尾素 复发 预测 |
| 英文关键词: Colorectal polyps Milk fat globule epidermal growth factor 8 Irisin Recurrence Prediction |
| 基金项目:河北省中医药管理局资助项目( 2022180) |
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| 中文摘要: |
| 目的探究血清乳脂肪球表皮生长因子 8(MFG-E8)、鸢尾素对结直肠息肉病人复发的预测价值。方法以石家庄市中医院 2021年 6—12月收治的 96例结直肠息肉病人为息肉组进行回顾性研究，另选取该院同期健康体检志愿者 96例为对照组。采用酶联免疫吸附测定( ELISA)检测所有受试者血清 MFG-E8、鸢尾素水平。术后随访半年，根据是否复发将息肉组病人分为复发组( 32例)和未复发组( 64例)，比较两组血清 MFG-E8、鸢尾素水平。采用受试者操作特征曲线( ROC曲线)分析血清 MFG-E8、鸢尾素对结直肠息肉病人复发的预测价值。结果息肉组血清 MFG-E8［(145.31±22.44)μg/L比( 92.39±15.65)μg/L］水平明显高于对照组( P<0.05)鸢尾素［( 5.17±0.82)ng/L比( 8.54±1.13)ng/L］水平明显低于对照组( P<0.05)。复发组血清 MFG-E8［(163.39±26.31)μg/L比(13，6.27±17.51)μg/L］水平明显高于未复发组(P<0.05)鸢尾素［(4.58±0.74)ng/L比( 5.46±0.86) ng/L］水平明显低于未复发组( P<0.05)。 MFG-E8、鸢尾素联合预测结直肠息肉病人复发，的 ROC曲线下面积( AUC)(0.87)显著大于 MFG-E8单独预测的 AUC(0.74)(P=0.030)及鸢尾素单独预测的 AUC(0.72)(P<0.05)。结论结直肠息肉病人血清 MFG-E8水平明显升高，鸢尾素水平明显降低，两者联合检测对于结直肠息肉病人复发具有一定的预测意义。 |
| 英文摘要: |
| Objective To explore the predictive value of serum milk fat globule epidermal growth factor 8 (MFG-E8) and irisin for the recurrence of colorectal polyps.Methods Retrospective study on 96 patients with colorectal polyps admitted to Shijiazhuang Tradi.tional Chinese Medicine Hospital from June to December 2021 as the polyp group, and 96 healthy volunteers were regarded as the con.trol group. The levels of serum MFG-E8 and irisin of all subjects were detected by enzyme-linked immunosorbent assay (ELISA). After half a year follow-up, the polyp group was separated into recurrence group (32 cases) and non-recurrence group (64 cases) according to the recurrence or not, and the levels of serum MFG-E8 and irisin were compared between the two groups. Receiver operating character.istic (ROC) curve was used to analyze the predictive value of serum MFG-E8 and irisin for the recurrence of colorectal polyps.Results The level of serum MFG-E8 [(145.31±22.44) μg/L vs. (92.39±15.65) μg/L] in the polyp group was obviously higher than that in the con. trol group (P<0.05), and the level of irisin [(5.17±0.82) ng/L vs. (8.54±1.13) ng/L] was obviously lower than that in the control group (P< 0.05). The level of serum MFG-E8 [(163.39±26.31) μg/L vs. (136.27±17.51) μg/L] in the recurrence group was obviously higher than that in the non-recurrence group (P<0.05), and the level of irisin [(4.58±0.74) ng/L vs. (5.46±0.86) ng/L] was obviously lower than that in the non-recurrence group (P<0.05). The area under the ROC curve (AUC) (0.87) of MFG-E8 combined irisin to predict the recur. rence of colorectal polyps was obviously larger than the AUC (0.74) predicted by MFG-E8 alone and the AUC(0.72) predicted by irisin alone (P<0.05).Conclusion The serum MFG-E8 level in patients with colorectal polyps is obviously increased, and the level of irisinis obviously decreased, and the combination of the two has certain predictive significance for the recurrence of patients with colorectalpolyps. |
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