| 姚洁,王尚臣,褚丽芳,等.血管性认知功能障碍病人血清微 RNA-335-5p、血清应答因子水平及其临床意义[J].安徽医药,2024,28(3):597-602. |
| 血管性认知功能障碍病人血清微 RNA-335-5p、血清应答因子水平及其临床意义 |
| Levels of serum microRNA-335-5P and serum response factor in patients with vascular cognitive impairment and their clinical significance |
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| DOI：10.3969/j.issn.1009-6469.2024.03.038 |
| 中文关键词: 认知功能障碍 微 RNA-335-5p 血清应答因子 脑卒中 美国国立卫生研究院卒中量表 |
| 英文关键词: Cognitive cognitive dysfunction MicroRNA-335-5p Serum response factor Stroke National Institute of Health Stroke Scale |
| 基金项目:石家庄市科学技术研究与发展计划项目( 211201313) |
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| 中文摘要: |
| 目的探究血管性认知功能障碍( VCI)病人血清微 RNA(miR)-335-5p、血清应答因子( SRF)水平及临床意义。方法以石家庄市人民医院 2019年 1月至 2020年 12月因脑卒中治疗后 6个月出现 VCI的 110例病人为研究对象( VCI组)其中非痴呆型血管性认知功能障碍( VCIND)者 48例( VCIND组)、血管性痴呆( VD)者 62例( VD组)。同时间段该院脑卒中未合，并认知障碍者 110例为对照组。分析各组病人发病时(入院次日)发病后 6个月、发病后 1年血清 miR-335-5p、SRF水平。 logistic回归模型分析脑卒中病人发生 VCI的影响因素。 Pearson法分析、血清 miR-335-5p与 SRF水平的相关性。受试者操作特征曲线(ROC曲线)分析血清 miR-335-5p、SRF水平对 VCI的预测价值。结果 VCI组发病时 miR-335-5p水平 0.76±0.15低于对照组 1.06±0.07，而 SRF水平 1.52±0.24高于对照组 1.01±0.09，差异有统计学意义( P<0.05)。发病时，对照组、 VCIND组、 VD组的 miR-335-5p水平逐次降低( 1.06±0.07比 0.86±0.17比 0.68±0.14)，SRF水平依次增加( 1.01±0.09比 1.32±0.25比 1.67±0.24)，差异有统计学意义( P<0.05)。 VD组、 VCIND组受试者在发病后 6个月及 1年时 SRF水平低于发病时，而 miR-335-5p水平高于发病时( P<0.05)。三组蒙特利尔认知评估量表( MoCA)评分、 miR-335-5p、SRF组间、时间、交互作用差异有统计学意义( P<0.05)。发病时， VCI组血清 miR-335-5p与 SRF水平存在负相关性( r=.0.64，P<0.001)。年龄、美国国立卫生研究院卒中量表( NIHSS)评分、 miR-335-5p、SRF是影响脑卒中病人 VCI的危险因素( P<0.05)。 ROC分析显示，血清 miR-335-5p、SRF、miR-335-5p联合 SRF预测脑卒中后 VCI的曲线下面积为 0.88［95%CI:(0.84，0.93)］、 0.90［95%CI:(0.86，0.95)］、 0.93［95%CI:(0.89，0.97)］。结论 VCI病人血清 miR-335-5p水平明显降低，而 SRF水平升高，二者水平变化与 VCI严重程度有关，是导致脑卒中后 VCI的影响因素，且二者联合对脑卒中后 VCI有较高预测效能。 |
| 英文摘要: |
| Objective To investigate the levels and clinical significance of serum microRNA (miR)-335-5p and serum response fac. tor (SRF) in patients with vascular cognitive impairment (VCI). Methods A total of 110 patients with VCI at 6 months after stroketreatment in Shijiazhuang People's Hospital from January 2019 to December 2020 were selected as the study subjects (VCI group), in.cluding 48 cases with vascular cognitive impairment with no dementia (VCIND group) and 62 cases with vascular dementia (VD group).In the same period, 110 patients with cerebral apoplexy without cognitive impairment were selected as the control group. The serum lev.els of miR-335-5p and SRF in each group were analyzed at the time of onset (the next day after admission), 6 months after onset, and 1year after onset. Logistic regression model was used to analyze the influencing factors of VCI in stroke patients. The correlation betweenserum miR-335-5p and SRF levels was analyzed by Pearson method. Receiver operating characteristic curve (ROC) was used to analyzethe predictive value of serum miR-335-5p and SRF levels for VCI.Results The level of miR-335-5p (0.76±0.15) in the VCI group waslower than that in the control group (1.06±0.07), while the level of SRF (1.52±0.24) was higher than that in the control group (1.01±0.09), and the difference was statistically significant (P<0.05). At the time of onset, the levels of miR-335-5p in the control group, VCIND group and VD group decreased successively (1.06±0.07 vs. 0.86±0.17 vs. 0.68±0.14), and the levels of SRF increased succes. sively (1.01±0.09 vs. 1.32±0.25 vs. 1.67±0.24), and the difference was statistically significant (P<0.05). The level of SRF in VD groupand VCIND group at 6 months and 1 year after onset was lower than that at onset, while the level of miR-335-5p was higher than that at onset (P<0.05). There were significant differences in MoCA score, miR-335-5p, SRF, time and interaction among the three groups (P< 0.05). At the time of onset, there was a negative correlation between the levels of serum miR-335-5p and SRF in VCI group (r=.0.64, P<0.001). Age, NIHSS score, miR-335-5p and SRF were risk factors for VCI in stroke patients (P<0.05). ROC analysis showed that the area under the curve of serum miR-335-5p, SRF, miR-335-5p combined with SRF in predicting VCI after stroke were 0.88 [95%CI: (0.84, 0.93)], 0.90 [95%CI: (0.86, 0.95)] and 0.93 [95%CI: (0.89, 0.97)], respectively.Conclusions The level of serum miR-335-5p inpatients with VCI is significantly decreased, while the level of SRF is increased. The changes of the two levels are related to the severityof VCI, which is the influencing factor of VCI after stroke. The combination of miR-335-5p and SRF has high predictive efficiency for VCI after stroke. |
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