| 赵阳,宋京京,常晓盼,等.温补肾阳单味中药及其有效成分防治骨质疏松症的可能分子机制研究进展[J].安徽医药,2024,28(4):648-653. |
| 温补肾阳单味中药及其有效成分防治骨质疏松症的可能分子机制研究进展 |
| Progress of research on the possible molecular mechanism of warming and reinforcing kidney-Yang single traditional Chinese medicine and their active ingredients in the prevention and treatment of osteoporosis |
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| DOI：10.3969/j.issn.1009-6469.2024.04.003 |
| 中文关键词: 骨质疏松 温补肾阳 骨代谢信号通路 分子机制 综述 |
| 英文关键词: Osteoporosis Warming kidney-Yang Osteogenic signal pathway Molecular mechanisms Review |
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| 摘要点击次数: 280 |
| 全文下载次数: 139 |
| 中文摘要: |
| 骨质疏松症( osteoporosis，OP)是一种代谢性骨病，以骨量下降、骨微结构损坏为主要临床特征，发病率呈现逐渐上升的趋势。中医学将 OP纳入“骨痿”“骨极”中医药被用于治疗 OP由来已久，便、验等优势。随着中“骨枯”等疾病范畴，具有简、廉、西医结合医学学科的深入融合发展，基础研究发现多种温补肾阳类单味中药及其有效成分可能通过调控 Wnt/β-连环蛋白(β-catenin)、骨形态生成蛋白( BMP)/Smads、磷脂酰肌醇 -3磷酸激酶 /AKT/雷帕霉素靶蛋白信号通路( PI3K/Akt/mTOR)等骨代谢相关信号通路以达到防治 OP的目的，这有可能从分子机制上肯定了中医药治疗 OP的科学性。该文综述杜仲、骨碎补等常见代表性温补肾阳类中药及其有效成分防治 OP的可能分子机制，以期为中医药临床治疗 OP的进一步研究应用提供参考。 |
| 英文摘要: |
| Osteoporosis (OP) is a metabolic bone disease characterised by decreased bone mass and damage to bone microstructure, theincidence of which has shown a gradual increase. In traditional Chinese medicine (TCM), OP is included in the category of diseases suchas "bone weakness" "bone dryness" and "bone pole". TCM has been used to treat OP for a long time and has the advantages of simplicity,convenience, inexpensiveness, and effectiveness. With the development of in-depth integration of Chinese and Western medicine disci?plines, basic research has found that a variety of single herbs and their active ingredients of warming kidney yang class may regulate bonemetabolism-related signaling pathways such as Wnt/β-catenin, BMP/Smads, PI3K/Akt/mTOR to prevent and treat OP, which may affirmthe scientific validity of Chinese medicine treatment of OP from the molecular mechanism. This paper reviews the possible molecularmechanisms of the common representative warming kidney-yang herbs such as Eucommia and Bonesetter and their active ingredients forthe prevention and treatment of OP, to provide a reference for further research and application of TCM in the clinical treatment of OP. |
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