| 姬泽萱,张长洪,冯平,等.血清人软骨糖蛋白 -39对慢性阻塞性肺疾病急性加重的诊断价值[J].安徽医药,2024,28(4):723-726. |
| 血清人软骨糖蛋白 -39对慢性阻塞性肺疾病急性加重的诊断价值 |
| Diagnostic value of serum YKL-40 in patients with acute exacerbation of chronic obstructive pulmonary disease |
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| DOI：10.3969/j.issn.1009-6469.2024.04.018 |
| 中文关键词: 肺疾病，慢性阻塞性 用力呼气量 人软骨糖蛋白 -39 降钙素原 C-反应蛋白 |
| 英文关键词: Pulmonary disease, chronic obstructive Forced expiratory volume YKL-40 Procalcitonin (PCT) C-reactive pro? tein (CRP) |
| 基金项目:河北省 2019年度医学科学研究课题计划项目( 20190119) |
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| 中文摘要: |
| 目的探讨血清人软骨糖蛋白 -39(YKL-40)对于慢性阻塞性肺疾病( COPD)急性加重( AECOPD)的诊断价值。方法纳入 2018年 9月至 2019年 6月在河北北方学院附属第一医院住院 AECOPD病人 85例及同期 70例 COPD稳定期病人作为对照组，受试者均检测血清 YKL-40、降钙素原(PCT)及 C反应蛋白( CRP)水平，收集各受试者在院检测的肺功能、血气分析结果。观察各指标在不同的 AECOPD临床分级的变化以及 YKL-40与相关临床参数的关系。结果两组 YKL-40(58.03±12.78)μg/L比(38.69±8.72)μg/L、PCT(7.54±2.71)μg/L比(3.72±1.79)μg/L、CRP(99.29±34.98)mg/L比( 52.91±27.77)mg/L比较均差异有统计学意义。随着病人病情加重， AECOPDⅠ、Ⅱ、Ⅲ级血清 YKL-40水平逐渐升高( 49.23±11.26)μg/L、(56.70±10.38)μg/L、(67.93±10.32)μg/L，各组间比较均差异有统计学意义(均 P<0.05)。 YKL-40与 PCT、CRP、动脉血二氧化碳分压( PaCO2)呈正相关，但与预测的第一秒用力呼气容积( FEV1)、第一秒用力呼气容积占预计值的百分比( FEV1%)、第一秒用力呼气量占用力肺活量百分率( FEV1/FVC)和动脉血氧分压( PaO2)呈负相关( P<0.05)。结论 AECOPD病人血清 YKL-40水平随病情加重而升高，升高程度与病情严重程度相关。 |
| 英文摘要: |
| Objective To investigate the diagnostic value of serum human cartilage glycoprotein-39 (YKL-40) in the diagnosis of acute exacerbation of chronic obstructive pulmonary disease (COPD) (AECOPD).Methods A total of 85 patients with AECOPD and70 patients with stable COPD in the First Affiliated Hospital of Hebei North University from September 2018 to June 2019 were en?rolled as the control group, and the serum levels of YKL-40, procalcitonin (PCT) and C-reactive protein (CRP) were measured, and theresults of lung function and blood gas analysis were collected. The changes of each index in different clinical grades of AECOPD andthe relationship between YKL-40 and related clinical parameters were observed.Results There were significant differences in YKL40 (58.03±12.78) μg/L vs. (38.69±8.72) μg/L, PCT (7.54±2.71) μg/L vs. (3.72±1.79) μg/L, and CRP (99.29±34.98) mg/L vs.(52.91± 27.77) mg/L. With the aggravation of the disease, the serum YKL-40 level gradually increased (49.23±11.26) μg/L, (56.70±10.38) μg/L, (67.93±10.32) μg/L, and the differences between the groups were statistically significant (all P<0.05). YKL-40 was positively corre? lated with PCT, CRP, and arterial carbon dioxide partial pressure (PaCO2), but negatively correlated with predicted forced expiratory volume in one second (FEV1), forced expiratory volume in one second as a percentage of predicted value (FEV1%), ratio of forced expira? tory volume in one second to occupied vital capacity (FEV1/FVC), and arterial partial pressure of oxygen (PaO2) (P<0.05).Conclusion The serum level of YKL-40 in patients with AECOPD increases with the severity of the disease, and the degree of elevation is related tothe severity of the disease. |
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