| 胡锦波,郭建平.预测甲状腺乳头状癌颈部中央区淋巴结转移生物标志物研究进展[J].安徽医药,待发表. |
| 预测甲状腺乳头状癌颈部中央区淋巴结转移生物标志物研究进展 |
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| 投稿时间：2023-09-25 录用日期：2023-10-30 |
| DOI： |
| 中文关键词: 甲状腺乳头状癌 颈部中央区淋巴结转移 生物标志物 |
| 英文关键词: |
| 基金项目:吕梁市重点研发项目(2020SHFZ63) |
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| 摘要点击次数: 292 |
| 全文下载次数: 0 |
| 中文摘要: |
| 甲状腺癌作为最常见的内分泌恶性肿瘤，发病率逐年上升。甲状腺乳头状癌作为其中最常见的病理分型，大部分患者预后较好，但颈部淋巴结转移作为其侵袭性特征，提示患者预后不良。目前国内外指南对于术前颈部淋巴结无明显转移征象患者是否需预防性行颈部中央区淋巴结清扫存在争议。液体活检具有便捷、无创等特点，多种血清标志物及基因突变靶点在甲状腺乳头状癌颈部淋巴结转移中的作用具有独特优势，并可联合影像学检查及细针穿刺活检提高诊断敏感性，但仍有不足之处。本文就甲状腺乳头状癌颈部中央区淋巴结转移相关的部分生物标志物进行综述。 |
| 英文摘要: |
| As the most common endocrine malignant tumor, the incidence of thyroid cancer is increasing year by year. Papillary thyroid carcinoma is the most common pathological type. Most patients have a good prognosis, but cervical lymph node metastasis is an invasive feature, suggesting a poor prognosis. At present, domestic and foreign guidelines are controversial about whether prophylactic central neck lymph node dissection is necessary for patients with no obvious signs of preoperative cervical lymph node metastasis. Liquid biopsy has the characteristics of convenience and non-invasiveness. A variety of serum markers and gene mutation targets have unique advantages in the role of cervical lymph node metastasis of papillary thyroid carcinoma, and can be combined with imaging examination and fine needle aspiration biopsy to improve the diagnostic sensitivity, but there are still deficiencies. This article reviews some biomarkers related to lymph node metastasis in the central neck of papillary thyroid carcinoma. |
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