| 赵晓利.血清CHI3L1、GDF15联合检测在乙肝相关原发性肝癌的早期诊断价值[J].安徽医药,待发表. |
| 血清CHI3L1、GDF15联合检测在乙肝相关原发性肝癌的早期诊断价值 |
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| 投稿时间：2023-12-15 录用日期：2024-04-16 |
| DOI： |
| 中文关键词: 壳多糖酶3样蛋白1 生长分化因子15 乙肝相关原发性肝癌 早期诊断 |
| 英文关键词: |
| 基金项目:大同市重点研发技术项目(2019093) |
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| 摘要点击次数: 70 |
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| 中文摘要: |
| 目的：探讨血清壳多糖酶3样蛋白1（CHI3L1）、生长分化因子15（GDF-15）水平联合检测对乙肝相关原发性肝癌早期诊断价值。方法：选取2021年1月-2023年6月我院收治的103例乙肝相关原发性肝癌患者（原发性肝癌组），96例肝纤维化患者（肝纤维化组），99例肝硬化患者（肝硬化组），105例慢性肝炎患者（慢性肝炎组）和100例体检健康人员（健康对照组）作为观察对象，ELISA检测各组研究对象血清CHI3L1、GDF15水平并进行比较；比较不同病理特征下原发性肝癌患者血清CHI3L1、GDF15水平；ROC评估血清CHI3L1、GDF15水平单独与联合检测对乙肝相关原发性肝癌早期诊断价值。结果：与健康对照组相比，慢性肝炎组、肝硬化组、肝纤维化组、原发性肝癌组血清CHI3L1、GDF15水平依次显著性升高（P＜0.05）；与单个肿瘤、肿瘤直径＜5 cm、TNM分期I～II期、无门静脉癌栓、无远处转移、无肝硬化、分化程度中、高分化、Child-Pugh肝功能分级A级及完整肿瘤包膜的原发性肝癌患者相比，多个肿瘤、肿瘤≥5 cm、TNM分期II～IV期、有门静脉癌栓、有远处转移、有肝硬化、低分化、Child-Pugh肝功能分级B级及不完整肿瘤包膜的患者血清CHI3L1、GDF15水平显著升高（P＜0.05）；血清CHI3L1、GDF15水平单独及二者联合预测是否发生乙肝相关原发性肝癌的AUC分别为0.787、0.787、0.860，二者联合预测AUC比单独预测的AUC显著增高（Z=2.096，P=0.036；Z=2.096，P=0.036）。结论：血清CHI3L1、GDF15水平在乙肝相关原发性肝癌患者体内高表达，二者单独及联合对乙肝相关原发性肝癌早期诊断均具有重要参考价值。 |
| 英文摘要: |
| Objective: To explore the value of combined detection of serum levels of chitosanase 3 like protein 1 (CHI3L1) and growth differentiation factor 15 (GDF-15) in the early diagnosis of hepatitis B related primary liver cancer. Methods: From January 2021 to June 2023, 103 patients with hepatitis B related primary liver cancer (primary liver cancer group), 96 patients with liver fibrosis (liver fibrosis group), 99 patients with cirrhosis (liver cirrhosis group), 105 patients with chronic hepatitis (chronic hepatitis group) and 100 healthy people (health control group) admitted to our hospital were regarded as the observation objects, ELISA was applied to detect and compare the serum levels of CHI3L1 and GDF15 of study subjects in each group; the serum levels of CHI3L1 and GDF15 in patients with primary liver cancer with different pathological characteristics were compared; ROC was applied to evaluate the value of serum CHI3L1 and GDF15 levels in the early diagnosis of hepatitis B related primary liver cancer. Results: Compared with the healthy control group, the serum levels of CHI3L1 and GDF15 in the chronic hepatitis group, liver cirrhosis group, liver fibrosis group, and primary liver cancer group were obviously increased in sequence (P<0.05); compared with primary liver cancer patients with a single tumor, tumor diameter<5 cm, TNM staging I-II, no portal vein tumor thrombus, no distant metastasis, no cirrhosis, moderate to high differentiation, Child-Pugh liver function grade A, and intact tumor capsule, the levels of serum CHI3L1 and GDF15 were obviously higher in patients with multiple tumors, tumors ≥ 5 cm, TNM staging II to IV, presence of portal vein tumor thrombi, distant metastasis, cirrhosis, low differentiation, Child-Pugh liver function grade B, and incomplete tumor capsule (P<0.05); the AUC of serum CHI3L1 and GDF15 levels alone and jointly in predicting the occurrence of hepatitis B related primary liver cancer was 0.787, 0.787 and 0.860, respectively, the AUC predicted by the combination of the two was obviously higher than the AUC predicted alone (Z=2.096, P=0.036; Z=2.096, P=0.036). Conclusion: Serum levels of CHI3L1 and GDF15 are highly expressed in patients with hepatitis B related primary liver cancer. Both alone and in combination have important reference value for early diagnosis of hepatitis B related primary liver cancer. |
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