| 朱小涛.血清vWF、MMP-9、GRP78联合检测对急性胰腺炎患者预后的预测价值[J].安徽医药,待发表. |
| 血清vWF、MMP-9、GRP78联合检测对急性胰腺炎患者预后的预测价值 |
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| 投稿时间：2024-01-24 录用日期：2024-04-19 |
| DOI： |
| 中文关键词: 血管性血友病因子 基质金属蛋白酶-9 葡萄糖调节蛋白78 急性胰腺炎 预后 |
| 英文关键词: |
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| 摘要点击次数: 76 |
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| 中文摘要: |
| 目的：探究血清血管性血友病因子（vWF）、基质金属蛋白酶-9（MMP-9）、葡萄糖调节蛋白78（GRP78）联合检测对急性胰腺炎患者预后的预测价值。方法：选取126例在本院2021年9月~2023年9月收治的急性胰腺炎患者作为研究组，根据亚特兰大分类将其分为轻症组（n=57）、中症组（n=50）、重症组（n=19）；根据预后状况分为预后不良组（n=34）、预后良好组（n=92）；另选取126例在本院进行健康体检者作为对照组。用ELISA法检测血清vWF、MMP-9、GRP78水平；患者预后的影响因素用多因素Logistic回归分析；血清vWF、MMP-9、GRP78对患者预后的预测价值用ROC曲线分析。结果：研究组血清vWF、MMP-9、GRP78水平均显著高于对照组（P＜0.05）；重症组血清vWF、MMP-9、GRP78表达水平均显著高于轻症组、中症组，且中症组血清vWF、MMP-9、GRP78表达水平均高于轻症组（P＜0.05）；预后不良组APACHEⅡ评分、血清CRP、vWF、MMP-9、GRP78水平均显著高于预后良好组（P＜0.05）；血清vWF、MMP-9、GRP78、APACHEⅡ评分为急性胰腺炎患者预后的影响因素（P＜0.05）；血清vWF、MMP-9、GRP78联合预测急性胰腺炎患者预后的曲线下面积（AUC）为0.928，高于各自单一检测（Z二者联合-MMP-9=2.380、Z二者联合-vWF=2.559，Z二者联合-GRP78=2.638，P=0.011、P=0.017、P=0.008）。结论：急性胰腺炎患者血清vWF、MMP-9、GRP78表达水平均明显升高，且是急性胰腺炎患者预后的影响因素，对患者预后有较高的预测价值。 |
| 英文摘要: |
| Objective: To explore the predictive value of combined detection of serum von Willebrand factor (vWF), matrix metalloproteinase-9 (MMP-9), and glucose regulated protein 78 (GRP78) for the prognosis of patients with acute pancreatitis. Methods: From September 2021 to September 2023, 126 patients with acute pancreatitis admitted to our hospital were regarded as the trail group, according to the Atlanta classification, they were separated into mild group (n=57), moderate group (n=50), and severe group (n=19); according to the prognosis, they were separated into a good prognosis group (n=92) and a poor prognosis group (n=34); 126 individuals who underwent health examinations in our hospital were included as the reference group. ELISA method was applied to detect serum vWF, MMP-9, and GRP78 levels; multivariate Logistic regression was applied to analyze the influencing factors of prognosis in patients with acute pancreatitis; ROC curve was applied to analyze the predictive value of serum vWF, MMP-9, and GRP78 for the prognosis of patients with acute pancreatitis. Results: The serum vWF, MMP-9, and GRP78 levels in the trail group were obviously higher than those in the reference group (P<0.05); the expression levels of serum vWF, MMP-9, and GRP78 in the severe group were obviously higher than those in the mild and moderate groups, and the expression levels of serum vWF, MMP-9, and GRP78 in the moderate group were higher than those in the mild group (P<0.05); the APACHE II score, serum CRP, vWF, MMP-9, and GRP78 levels in the poor prognosis group were obviously higher than those in the good prognosis group (P<0.05); serum vWF, MMP-9, GRP78, and APACHE II scores were prognostic factors for patients with acute pancreatitis (P<0.05); the area under the curve (AUC) of the combined prediction of serum vWF, MMP-9, and GRP78 for prognosis in patients with acute pancreatitis was 0.928, which was better than the individual detection of serum vWF, MMP-9, and GRP78 (Z combined prediction - MMP-9=2.380, Z combined prediction - vWF=2.559, Z combined prediction - GRP78=2.638, P=0.011, P=0.017, P=0.008). Conclusion: The expression levels of serum vWF, MMP-9, and GRP78 in patients with acute pancreatitis are obviously increased, and they are influencing factors for the prognosis of patients with acute pancreatitis, with high predictive value for prognosis. |
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