| 孙涛,张示渊.CYFRA21-1在非酒精性脂肪性肝病并发2型糖尿病患者中的表达及与胰岛素抵抗的关系[J].安徽医药,待发表. |
| CYFRA21-1在非酒精性脂肪性肝病并发2型糖尿病患者中的表达及与胰岛素抵抗的关系 |
|
| 投稿时间：2024-02-20 录用日期：2024-04-17 |
| DOI： |
| 中文关键词: 非酒精性脂肪性肝病 2型糖尿病 细胞角蛋白19片段 胰岛素抵抗 相关性 |
| 英文关键词: |
| 基金项目: |
|
| 摘要点击次数: 50 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的：探讨非酒精性脂肪性肝病（NAFLD）并发2型糖尿病（T2DM）患者中细胞角蛋白19片段（CYFRA21-1）与胰岛素抵抗（IR）的相关性。方法：选取我院2020年6月~2023年6月收治的291例NAFLD患者作为研究对象，根据NAFLD患者是否并发T2DM将其分为NAFLD并发T2DM患者（T2DM组，133例）和NAFLD未并发T2DM患者（非T2DM组，158例）。收集两组患者年龄、性别等一般临床资料，并检测患者CRP、FPG、FINS、ALT、TC、TG等生化指标及CYFRA21-1水平，并计算胰岛素抵抗指数（HOMA-IR）以及胰岛素敏感指数（ISI）。采用logistic回归分析NAFLD患者并发T2DM的影响因素；采用Pearson相关分析NAFLD并发T2DM患者CYFRA21-1与HOMA-IR、ISI的相关性。结果：非T2DM组与T2DM组的年龄、性别、BMI、收缩压、舒张压、ALT、AST、TC、TG、LDL-C水平无显著性差异（P＞0.05）；T2DM组患者CRP、FPG、FINS、GGT水平显著高于非T2DM组（P＜0.05），HDL-C水平显著低于非T2DM组（P＜0.05）；与非T2DM组相比，T2DM组患者CYFRA21-1、HOMA-IR水平显著升高（P＜0.05），ISI水平显著降低（P＜0.05）；logistic回归结果显示，CYFRA21-1、HOMA-IR、CRP、FPG、FINS、GGT水平均是导致NAFLD患者并发T2DM的独立危险因素（P＜0.05），ISI、HDL-C均是NAFLD患者并发T2DM的独立保护因素（P＜0.05）；Pearson相关分析显示NAFLD并发T2DM患者血清CYFRA21-1与HOMA-IR水平呈现正相关（r=0.691，P＜0.001），CYFRA21-1与ISI水平呈现负相关（r=-0.600，P＜0.001）。结论：NAFLD并发T2DM患者CYFRA21-1、HOMA-IR水平显著升高，ISI水平显著降低，且CYFRA21-1水平与HOMA-IR、ISI水平有密切关系。 |
| 英文摘要: |
| Objective: To investigate the correlation between cytokeratin 19 fragment (CYFRA21-1) and insulin resistance (IR) in patients with non-alcoholic fatty liver disease (NAFLD) complicated with type 2 diabetes mellitus (T2DM). Methods: A total of 291 NAFLD patients accepted by our hospital from June 2020 to June 2023 were regarded as the study subjects, NAFLD patients were separated into NAFLD patients with T2DM (133 cases in the T2DM group) and NAFLD patients without T2DM (158 cases in the non T2DM group) based on whether they were complicated with T2DM. General clinical data such as age and gender of both groups were collected, biochemical indicators such as CRP, FPG, FINS, ALT, TC, TG, and CYFRA21-1 levels in patients were detected, the insulin resistance index (HOMA-IR) and insulin sensitivity index (ISI) were calculated. Logistic regression was applied to analyze the influencing factors of T2DM in NAFLD patients; Pearson correlation was applied to analyze the correlation between CYFRA21-1, HOMA-IR, and ISI in patients with NAFLD complicated with T2DM. Results: There was no obvious difference in age, gender, BMI, systolic blood pressure, diastolic blood pressure, ALT, AST, TC, TG, LDL-C levels between the non T2DM group and the T2DM group (P>0.05); the levels of CRP, FPG, FINS, and GGT in the T2DM group were obviously higher than those in the non T2DM group (P<0.05), while the level of HDL-C was obviously lower than that in the non T2DM group (P<0.05); compared with the non T2DM group, the levels of CYFRA21-1 and HOMA-IR in the T2DM group were obviously higher (P<0.05), while the level of ISI was obviously lower (P<0.05); logistic regression results showed that CYFRA21-1, HOMA-IR, CRP, FPG, FINS, and GGT levels were all independent risk factors for T2DM in NAFLD patients (P<0.05), while ISI and HDL-C were independent protective factors for NAFLD patients with T2DM (P<0.05); Pearson correlation analysis showed there was a positive correlation between serum CYFRA21-1 and HOMA-IR levels in patients with NAFLD complicated by T2DM (r=0.691, P<0.001), and there was a negative correlation between CYFRA21-1 and ISI levels (r=-0.600, P<0.001). Conclusion: The levels of CYFRA21-1 and HOMA-IR in patients with NAFLD complicated by T2DM obviously increase, while ISI level obviously decreases. The CYFRA21-1 level is closely related to HOMA-IR and ISI levels. |
|
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
