| 任志红,赵璇,曾玲,等.哮喘及肺炎患儿血浆白细胞介素-18、白细胞介素-16、 白细胞介素-4及γ-干扰素水平的相关性及临床意义[J].安徽医药,2018,22(1):85-87. |
| 哮喘及肺炎患儿血浆白细胞介素-18、白细胞介素-16、 白细胞介素-4及γ-干扰素水平的相关性及临床意义 |
| Correlation and clinical significance of plasma interleukin-18,-16,-4 and IFN-γ level in children with asthma and pneumonia |
| 投稿时间：2016-08-08 |
| DOI： |
| 中文关键词: 哮喘 肺炎 小儿 白细胞介素-18 白细胞介素-16 白细胞介素-4 γ-干扰素 |
| 英文关键词: asthma pneumonia children interleukin-18 interleukin-16 interleukin-4 interferon gamma-γ |
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| 中文摘要: |
| 目的 探讨哮喘及肺炎患儿血浆白细胞介素(IL)-18、IL-16、IL-4及γ-干扰素(IFN-γ)水平的相关性及临床意义。方法 研究对象为哮喘患儿(哮喘组)33例,肺炎患儿(肺炎组)38例,健康小儿40例(对照组),采用酶联免疫吸附实验(ELISA)测定研究对象血浆IL-18、IL-16、IL-4及IFN-γ水平,并比较各指标的相关性。结果 哮喘患儿急性发作期和非发作期血浆IL-16、IL-4水平与对照组比较,差异有统计学意义(F=15.687、18.359,P<0.05),血浆IL-18和IFN-γ水平,在急性发作期、非发作期与对照组相比,差异无统计学意义(F=3.025、4.367,P>0.05)。肺炎患儿急性期和恢复期血浆IL-18、IL-16水平与对照组相比,差异有统计学意义(F=24.386、31.256,P<0.05),血浆IL-4和IFN-γ水平,在急性期、恢复期与对照组相比,差异无统计学意义(F=5.328、5.587,P>0.05)。哮喘患儿血浆中IL-18与IL-4、IFN-γ之间,IL-16与IL-18、IL-4、IFN-γ之间显著正相关(P<0.05)；IL-4与IFN-γ之间存在显著负相关(P<0.05)。肺炎患儿血浆中IL-18与IL-16、IL-4、IFN-γ之间,IL-16与IFN-γ之间显著正相关(P<0.05)。结论 IL-18、IL-16、IL-4、IFN-γ参与了小儿哮喘和肺炎的免疫反应过程。 |
| 英文摘要: |
| Objective To explore the correlation and clinical significance of plasma interleukin-18,-16,-4 and IFN-γ level in children with asthma and pneumonia. Methods Thirty-three cases with asthma (asthma group),38 cases with pneumonia (pneumonia group),and 40 healthy children (control group) were collected in the study.The plasma levels of IL-18,IL-16,IL-4 and IFN-γ were measured by enzyme-linked immunosorbent assay (ELISA),and the correlations of the indexes were compared. Results Compared with the control group,the plasma levels of IL-16 and IL-4 in children with asthma at acute and non-attack periods were significantly different (F=15.687,18.359,P<0.05).The plasma levels of IL-18 and IFN-γ had not significant differences between the acute and non-attack periods (F=3.025,4.367,P>0.05).The levels of IL-18 and IL-16 in children with pneumonia at acute and convalescent periods were significantly different from those in the control group (F=24.386,31.256,P<0.05).The plasma levels of IL-4 and IFN-γ had not significant differences between the acute and convalescent periods compared with the control group (F=5.328,5.587,P>0.05).There were significant positive correlations between IL-18 and IL-4,IFN-γ,IL-16 and IL-18,IL-4,IFN-γ in children with asthma (P<0.05),and there was a significant negative correlation between IL-4 and IFN-γ (P<0.05).There were significant positive correlations between IL-18 and IL-16,IL-4,IFN-γ,IL-16 and IFN-γ in children with pneumonia (P<0.05). Conclusions IL-18,IL-16,IL-4 and IFN-γ are involved in the immune response of children with asthma and pneumonia. |
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