| 张东伟,蓝冰.白细胞介素-32在不同分期哮喘患者血清中的含量比较[J].安徽医药,2018,22(5):912-915. |
| 白细胞介素-32在不同分期哮喘患者血清中的含量比较 |
| Comparison of the concentration of serum IL-32 in asthma patients with different stage |
| 投稿时间：2017-06-15 |
| DOI： |
| 中文关键词: 白细胞介素-32 哮喘 不同分期 |
| 英文关键词: interleukin-32 asthma different stages |
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| 中文摘要: |
| 目的 探讨炎性细胞因子白细胞介素-32(IL-32)在哮喘患者血清中的含量及其意义。 方法 选择165例哮喘患者(包括急性发作期65例、慢性持续期42例及稳定期58例)作为研究对象,并以50例健康者为对照。采用酶联免疫吸附法检测血清IL-32。测定患者肺功能各指标,嗜酸性粒细胞(EOS)数量和嗜酸性细胞阳离子蛋白(ECP)水平,哮喘控制测试(ACT)评分,并分析IL-32与各指标相关性。 结果 IL-32在哮喘急性发作期组、慢性持续期组、稳定期组、健康对照组中的含量分别是(53.87±20.07)、(43.48±7.17)、(29.55±6.26)、(13.68±4.16) ng·L-1,随着病情从急渐缓,IL-32水平也逐渐下降。第一秒用力呼气量(FEV1)、FEV1/FVC和最大呼气峰流速指数(PEF)随病情的缓解而升高；EOS和ECP随病情的缓解而下降；ACT评分随病情的缓解越来越高。血清中IL32的含量与FEV1/FVC、PEF、EOS、ECP和ACT存在相关性,差异有统计学意义(P＜0.05),其中与EOS和ECP相关性最强；血清中IL32的含量与FEV1不具有相关性。 结论 IL-32与哮喘的发生发展过程密切相关,动态监测患者血清中IL-32的含量可为患者的诊断、病情评估及治疗提供帮助。 |
| 英文摘要: |
| Objective To investigate the expression and significance of interleukin -32 (IL-32) in serum of patients with asthma. Methods One hundred and sixty-five cases of asthma patients (including 65 cases of acute attack,42 cases of chronic duration and stable period of 58 cases) were selected as the research object,and 50 cases of healthy persons as the control.Enzyme linked immunosorbent assay was used to detect serum IL-32.The indexes of lung function in patients,the number of EOS and ECP levels,ACT score were measured,and the correlation between IL-32 and each index was analyzed. Results The expressions of IL-32 in acute asthma group,chronic persistent group,stable group and healthy control group were (53.87±20.07),(43.48±7.17),(29.55±6.26),(13.68±4.16) ng·L-1,the level of IL-32 gradually decreased as the disease slowed down.FEV1,FEV1/FVC and PEF increased with the remission of the disease;EOS and ECP decreased with the remission of the disease;ACT score with the remission of the disease is more and more high.The expression of IL-32 in serum was significantly correlated with FEV1/FVC,PEF,EOS,ECP and ACT(P＜0.05).The expression of IL-32 in serum was not correlated with FEV1. Conclusions IL-32 is closely related to the occurrence and development of asthma.The expression of IL-32 in the serum of patients with dynamic monitoring can provide help for the diagnosis,evaluation and treatment of the disease. |
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