| 谢强,汪世存.氨基酸代谢PET-CT探针L-[S-11C-甲基]-蛋氨酸的全自动合成及质量控制[J].安徽医药,2018,22(8):1562-1565. |
| 氨基酸代谢PET-CT探针L-[S-11C-甲基]-蛋氨酸的全自动合成及质量控制 |
| Automatic synthesis and quality control of amino acid metabolism PET-CT probe L-[S-11C- methyl] methionine |
| 投稿时间：2017-10-18 |
| DOI： |
| 中文关键词: 正电子发射断层显像/X射线断层扫描 氢碘酸 L-高胱氨酸硫内酯[11C]-蛋氨酸 |
| 英文关键词: Positron emission tomography-computed tomography Hydriodic acid L-homocysteine thiolactone [11C]-MET |
| 基金项目:国家自然科学基金青年科学基金项目(81501187),安徽省自然科学基金青年项目(1508085QH173) |
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| 中文摘要: |
| 目的 研究氨基酸代谢显像剂L-[S-11C-甲基]-蛋氨酸([11C]-MET)全自动合成、质量控制以及影响因素。方法 运用医用回旋加速器轰击氮氧混合气体,生产出的[11C-]与57%氢碘酸生成[11C]-碘代甲烷,高纯氮气推动[11C]-碘代甲烷与[11C]-MET前体L-高胱氨酸硫内酯反应,生成[11C]-MET,经纯化,灭菌最终得到[11C-MET注射液。薄层色谱法对[11C-MET进行放射化学纯度(RCP)检测。肿瘤患者行[11C-MET PET-CT扫描。结果 最终合成产物[11C]-MET的RCP>95%,3 mg的L-高胱氨酸硫内酯可获得未校正合成效率约为35%。结论 使用国产碳-11碘代甲烷合成模块以及碳-11多功能合成模块的组成化学合成模块实现液相法转移[11C-]两步法合成[11C]-MET,合成时间短,合成稳定。 [HT5"H] |
| 英文摘要: |
| Objective The present study aims to discuss the method for automatic produce, quality control of amino acid metabolism imaging agent L-[S-11C-methyl] methionine([11C]-MET) and the related factors. Methods Medical cyclotron firstly produced 11C-]by bombarding gas mixture of oxygen and nitrogen, and then interacted with 57 % hydriodic acid to produce [11C-CH3I. High purity of nitrogen promoted [11C]-CH3I interacting with the precursor [11C-MET L-homocysteine thiolactone to generate [11C]-MET. After purification and sterilization, we finally got [11C]-MET injection. The radiochemical purity(RCP) of [11C]-MET was detected by thin-layer chromatography(TLC). Patients with tumors underwent [11C]-MET PET-CT scan. Results The RCP of[11C]-MET is more than 97%.Three milligram of L-homocysteine thiolactone obtained an uncorrected synthetic efficiency about 35%. Conclusion The method to automatically generate [11C]-MET was easy,by which the time was short,and the method was stable. |
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