| 周锐,董慧明,黄建康,等.斑蝥酸钠维生素B6注射液对青年乳腺癌术后化疗的影响[J].安徽医药,2018,22(8):1575-1578. |
| 斑蝥酸钠维生素B6注射液对青年乳腺癌术后化疗的影响 |
| Effect of cantharis acid sodium vitamin B6 injection on youth postoperative chemotherapy patients with breast cancer |
| 投稿时间：2017-03-15 |
| DOI： |
| 中文关键词: 斑蝥酸钠维生素B6 乳腺肿瘤 免疫功能 化疗 |
| 英文关键词: Cantharis acid sodium vitamin B6 Breast tumor Immune function Chemotherapy |
| 基金项目:安徽省高等学校自然科学基金(KJ2015B097by)斑蝥酸钠维生素B6注射液对青年乳腺癌术后化疗的影响周锐,董慧明,黄建康,陈春春,彭德峰,朱金海,朱正志,崔振,王岩岩 (蚌埠医学院第一附属医院肿瘤外科,安徽 蚌埠 233000) |
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| 中文摘要: |
| 目的 观察斑蝥酸钠维生素B6注射液联合化疗对青年乳腺癌术后化疗患者的临床效果。方法 87例患者按照随机数字表法分为对照组(n=42) 和观察组(n =45) 。观察组在对照组基础上联合斑蝥酸钠维生素B6注射液治疗。对比分析两组治疗前后血常规、肝肾功能、心电图、T 细胞亚群、自然杀伤(NK)细胞情况。结果 经治疗后,观察组的白细胞及血小板计数下降(11例比3例)、肝功能异常患者所占比例(15例比6例)均低于对照组,T 细胞亚群及NK 细胞占比[(67.2±8.5)%比(42.3±5.9)%]高于对照组,均差异有统计学意义(P<0.05)。两组患者中肾功能及心电图异常差异无统计学意义。结论 斑蝥酸钠维生素B6注射液联合化疗治疗青年乳腺癌术后化疗患者,可以降低骨髓抑制发生率,改善肝功能,提高患者的免疫功能。 |
| 英文摘要: |
| Objective To observe the clinical effect of cantharis acid sodium vitamin B6 injection combined with chemotherapy on youth postoperative patients with breast cancer.Methods 87 patients were randomly divided into the control group (n=42) and observation group (n=45) according to random number table method. The observation group received cantharis acid sodium vitamin B6 injection on the basis of the control group.Comparison of the blood routine, liver and kidney function, electrocardiogram (ECG), T cell subsets and natural killer (NK) cells of the two groups before and after treatment were analyzed.Results After treatment, the observation group of the proportion of patients with decreasing of blood cell and platelet count (11 vs. 3) and abnormal liver function (15 vs. 6) were lower than the control group. T cell subsets and NK cells [(67.2±8.5)% vs. (42.3±5.9)%] proportion was higher than the control group. The differences were statistically significant (P<0.05). The abnormal ECG and renal function between the two groups had no statistical significance. Conclusion Cantharis acid sodium vitamin B6 injection combined with chemotherapy can reduce the incidence of bone marrow suppression, improve liver function and the immune function on youth postoperative patients with breast cancer. |
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