| 戴春燕,于蒙恩,任建强.普拉洛芬联合重组牛碱性成纤维细胞生长因子滴眼液治疗过敏性结膜炎的临床效果观察[J].安徽医药,2019,23(7):1445-1447. |
| 普拉洛芬联合重组牛碱性成纤维细胞生长因子滴眼液治疗过敏性结膜炎的临床效果观察 |
| Clinical observation of pranoprofen combined with recombinant bovine basic fibroblast growth factor eye drops in the treatment of allergic conjunctivitis |
| 投稿时间：2017-08-08 |
| DOI： |
| 中文关键词: 普拉洛芬 贝复舒 过敏性结膜炎 |
| 英文关键词: Pranoprofen Recombinant bovine basic fibroblast growth factor Allergic conjunctivitis |
| 基金项目: |
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| 摘要点击次数: 2522 |
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| 中文摘要: |
| 目的 观察普拉洛芬联合重组牛碱性成纤维细胞生长因子(贝复舒)滴眼液治疗过敏性结膜炎的临床疗效及其对干眼症的预防作用。方法 选取2015年8月至2017年4月无锡市锡山人民医院收治的过敏性结膜炎病人116例,采用随机数字表法分成对照组与观察组,每组各58例。对照组予普拉洛芬滴眼液治疗,观察组予普拉洛芬联合贝复舒滴眼液治疗。连续治疗2周后比较两组症状与体征的变化并评价疗效差异,记录治疗前后泪膜破裂时间(break up time,BUT)、角膜荧光素染色(corneal fluorescent staining,FL)评分。结果 两组病人中对照组治愈19例,显效17例,有效率62.07%；观察组治愈28例,显效19例,有效率81.03%,两组有效率比较,差异有统计学意义(P<0.05)。两组病人治疗后BUT、FL评分均较治疗前改善(P<0.05)。治疗后观察组BUT(10.55±1.80)s高于对照组BUT(9.62±1.67)s,观察组FL评分 (0.83±0.68)分显著低于对照组(1.59±0.94)分,均差异有统计学意义(P<0.05)。结论 普拉洛芬联合贝复舒滴眼液治疗过敏性结膜炎具有较好的临床效果且具有预防干眼症的作用。 |
| 英文摘要: |
| ObjectiveTo evaluate the clinical efficacy of pranoprofen combined with recombinant bovine basic fibroblast growth factor eye drops in the treatment of allergic conjunctivitis and the preventive effect of dry eye.Methods 116 patients with allergic conjunctivitis from August 2015 to April 2017 were randomly divided into two groups:the control group (n=58) treated with pranoprofen eye drop;the observation group (n=58) treated with pranoprofen combined with recombinant bovine basic fibroblast growth factor eye drops.After two weeks of continuous treatment,the symptoms and signs were observed before and after the treatment,respectively.The clinical efficiency was evaluated.Break-up time of tear film (BUT) and corneal fluorescent staining (FL) score before and after the treatment were compared between the 2 groups.Results In the control group,19 cases were cured,17 cases were markedly effective,the effective rate was 62.07%.In the observation group,28 cases were cured,19 cases were markedly effective,the effective rate was 81.03%.There was a statistically significant difference between the two groups(P＜0.05).BUT and the scores of FL after treatment were better than before treatment (P<0.05).BUT (10.55±1.80)s in the observation group were higher than BUT (9.62±1.67)s in the control group after the treatment (P＜0.05).And the scores of FL(0.83±0.68) in the observation group were significantly lower than the scores of FL(1.59±0.94) in the control group after the treatment (P＜0.05).Conclusion Pranoprofen combined with recombinant bovine basic fibroblast growth factor eye drops treatment,with the moderate clinical efficacy of allergic conjunctivitis,can prevent dry eye. |
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