| 李争艳,陈凌云,罗静,等.龙血竭-羟丙基-β-环糊精包合物的制备及评价[J].安徽医药,2019,23(9):1745-1749. |
| 龙血竭-羟丙基-β-环糊精包合物的制备及评价 |
| Preparation and characterization of dragon’s blood- HP-β-CD inclusion compound |
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| DOI：10.3969/j.issn.1009-6469.2019.09.012 |
| 中文关键词: 龙血竭 羟丙基-β-环糊精 包合物 制备 色谱法，高压液相 |
| 英文关键词: Dragon’s blood HP-β-CD Inclusioncompound Preparation Chromatography,high pressure liquid |
| 基金项目:国家自然科学基金资助项目(81360581)；昆明市科技计划项目(2015-1-S-00669，2016-1-S-03316) |
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| 中文摘要: |
| 目的 制备龙血竭与羟丙基-β-环糊精(HP-β-CD)包合物，提高龙血竭的溶解度。方法 通过测定龙血素A、B的含量，计算包合率和包合物收率。在单因素试验的基础上，以包合时间、包合温度、龙血竭与羟丙基-β-环糊精的质量比为影响因素，以包合率和包合物收率的综合评分为评价指标，使用正交试验法优化龙血竭的包合工艺。采用紫外光谱扫描法、差示扫描量热法、溶解度测定法对包合物进行评价。结果 最佳包合工艺:包合时间2 h，包合温度40 ℃，龙血竭与HP-β-CD质量之比为1∶8，采用优选的工艺条件制备的龙血竭羟丙基-β-环糊精包合物的平均包合率为86.85%，平均收率为79.18%。结论 该工艺的包合率及包合物收率较高，包合效果较好，可以明显提高龙血竭的溶解度。 |
| 英文摘要: |
| Objective Preparation of dragon’s blood-HP-β-CD inclusion compounds to improve the solubility of dragon’s blood.Methods By measuring the content of dragon blood A，B，calculating the inclusion rate and yield of inclusion，based on the single factor experiment，the preparation process was optimized by orthogonal test with inclusion time，inclusion temperature and ratio of dragon’s blood to HP-β-CD as influencing factors，and inclusion rate and drug yield as evaluation index.The characterization was performed by UV spectroscopy，differential scanning calorimetry and solubility determination.Results The results showed that optimum preparation conditions for dragon’s blood-HP-β-CD inclusion compound was as follow:the time of 2h，the temperature of 40℃ and dragon’s blood to HP-β-CD ratio of 1∶8.Under the optimized conditions，the inclusion rate of dragon’s blood-HP-β-CD inclusion compound was 86.85%，the drug yield was 79.18%.Conclusion The process can improve the rate of inclusion and drug yield，and the solubility of dragon’s blood. |
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