| 王雅,邹泽,李飞,等.中成药不良反应 159例报告分析[J].安徽医药,2019,23(11):2320-2323. |
| 中成药不良反应 159例报告分析 |
| Analysis of 159 ADR reports induced by Chinese patent medicine |
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| DOI：10.3969/j.issn.1009?6469.2019.11.054 |
| 中文关键词: 中成药 药物毒性 药物副反应报告系统 回顾性分析 |
| 英文关键词: Chinese patent drugs Drug toxicity Adverse drug reaction reporting systems Retrospective analysis |
| 基金项目:重庆市医学科研计划项目(20143028) |
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| 中文摘要: |
| 目的探讨中成药发生药品不良反应( ADR)的原因及其特点，为促进临床合理用药提供参考。方法对 2016年 1月至 2017年 12月重庆市黔江中心医院 159例中成药所致 ADR报告采用回顾性研究方法，分别从年龄、性别、发生时间、累及系统 /器官及临床表现、关联性评价及转归等方面进行统计、分析。结果以 60~74岁老年病人的 ADR发生率最高( 0.13%)；给药途径以静脉给药为主( 50.94%)； ADR多发生于使用后 1h以内( 48.42%)； ADR表现以皮肤及附件损害最为常见( 37.44%)。结论中成药 ADR的发生与个体差异、药物本身及临床不合理使用等因素有关，应重视和加强 ADR监测，并加强对中成药生产和临床使用的安全监管，保障病人用药安全。 |
| 英文摘要: |
| Objective To analyze the reasons and the characteristics of adverse drug reactions(ADR)induced by Chinese patent medicine in our hospital and to provide reference for rational medication.Methods A retrospective study was conducted on the re?ports on ADR collected from our hospital for ADR monitoring by statistical work.The analysis was made on indexes，such as the age，gender，route of administration，occurrence time，systems/organs involved and clinical manifestations，relevance evaluation and prognosis，etc.Results Highest incidence of ADR occurred among patients aged from 60?74 years old(0.13%).Intravenous admin? istration was the main route(50.94%).ADR mostly occurred over 1 hour after medication(48.42%).Systems/organs involved in ADR were mainly lesion of skin and its appendants(37.44%).Conclusion The specific causes of ADR are the factors of the indi? vidual differences，the drug itself，and irrational use of medicines.The government should pay attention and strengthen supervision over monitoring ADR，the pharmaceutical production and clinical application，so as to ensure the medical safety of the patients. |
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