| 陈秀秉,韦月辉,钟健,等.文拉法辛联合奥氮平治疗功能性胃肠病伴明显焦虑障碍 55例[J].安徽医药,2020,24(11):2283-2286. |
| 文拉法辛联合奥氮平治疗功能性胃肠病伴明显焦虑障碍 55例 |
| Venlafaxine combined with olanzapine in the treatment of functional gastrointestinal disorders with significant anxiety disorder:55 cases |
| |
| DOI：10.3969/j.issn.1009?6469.2020.11.043 |
| 中文关键词: 胃肠疾病/药物疗法 功能性胃肠病 焦虑 奥氮平 文拉法辛 疗效 |
| 英文关键词: Gastrointestinal diseases/drug therapy Functional gastrointestinal disorders Anxiety Olanzapine Venlafaxine Effect |
| 基金项目: |
|
| 摘要点击次数: 2074 |
| 全文下载次数: 418 |
| 中文摘要: |
| 目的比较文拉法辛联合奥氮平治疗功能性胃肠病(FGIDs)伴明显焦虑障碍病人的临床疗效。方法选取 2018年 1—9月在钦州市第一人民医院住院治疗的 110例 FGIDs病人为研究对象，采用随机数字表法分为对照组和观察组各 55例。两组病人均给予调节肠道菌群、抑酸护胃等基础治疗，对照组加服文拉法辛治疗，观察组在此基础上联合服用奥氮平治疗，疗程为 24周。比较两组病人治疗开始 0、1、2、4、24周的消化道症状(GSRS)、汉密尔顿焦虑量表(HAMA)以及汉密尔顿抑郁量表(HAMD)评分，比较治疗期间两组病人的不良反应发生情况。结果治疗后两组病人的 GSRS、HAMA、HAMD评分均明显下降(均 P＜0.001)。治疗 1周后，观察组 HAMA、HAMD评分均低于对照组(均 P＜0.05)。对照组与观察组不良反应发生率(66.7%比 69.4%)比较，差异无统计学意义(P＝0.771)。结论对伴明显焦虑障碍 FGIDs病人，文拉法辛能有效改善焦虑抑郁症状，但加入小剂量奥氮平后起效更快、效果更明显，具有较高安全性，值得临床推广。 |
| 英文摘要: |
| Objective To compare the clinical efficacy of venlafaxine combined with olanzapine in patients with functional gastro? enteropathy(FGIDs)with significant anxiety disorder.Methods A total of 110 patients with FGIDs in the First People’s Hospitalof Qinzhou from January 2018 to September 2018 were selected as study subjects and randomly divided into the control group(55 cases)and the observation group(55 cases).All patients were given basic treatment such as intestinal flora regulation，acid inhibi? tion and gastric protection.The control group was treated with venlafaxine，and the observation group was treated with olanzapine on this basis for 24 weeks.Gastrointestinal symptoms score(GSRS)，Hamilton anxiety scale(HAMA)and Hamilton depression scale(HAMD)were scored and compared between the two groups at 0，1，2，4 and 24 weeks，and adverse reactions were statistically ana? lyzed.Results GSRS，HAMA and HAMD scores of patients in the two groups after treatment were significantly lower than those before treatment(all P＜0.001).After 1 week of treatment，HAMA and HAMD scores in the observation group were significantly lower than those in the control group(all P＜0.05).The incidence of adverse reactions in the observation group(69.4%) was slightly higher than that in the control group(66.7%)，and the difference was not statistically significant(P＝0.771).Conclusion For FGIDs patients with obvious anxiety disorder，venlafaxine can effectively improve the symptoms of anxiety and depression，but the addition of small doses of olanzapine has faster onset，more obvious effect and also safety，which is worthy of clinical promotion. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
