| 陈宗科,陈晶晶,顾萍,等.肾上腺外副神经节瘤 47例临床病理分析[J].安徽医药,2020,24(12):2419-2421. |
| 肾上腺外副神经节瘤 47例临床病理分析 |
| Extra?adrenal paraganglioma:a clinicopathologic analysis of 47 cases |
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| DOI：10.3969/j.issn.1009?6469.2020.12.022 |
| 中文关键词: 副神经节瘤，肾上腺外 嗜铬粒蛋白质 A 突触素 神经细胞黏附分子 56(CD56) 病理学 免疫组织化学 |
| 英文关键词: Paraganglioma,extra?adrenal Chromogranin A Synapses Neuronal cell adhesion molecules 56(CD56) Pathology Immunohistochemistry |
| 基金项目:安徽省自然科学基金项目(1808085MH286) |
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| 中文摘要: |
| 目的探讨肾上腺外副神经节瘤临床病理特点、生物学行为。方法对安徽省立医院 2013年 1月至 2018年 12月 47例肾上腺外副神经节瘤病例的临床表现、组织学特点及免疫组织化学染色结果进行分析。结果 47例肾上腺外副神经节瘤，其中男性 23例，女性 24例，年龄范围为 31~75岁，平均年龄 51.0岁。 24例位于腹膜后， 20例位于头颈部， 3例位于膀胱。 1例位于腹膜后者伴有肝转移，其余 46例术中未发现远处转移。肿瘤实质由主细胞和支持细胞组成。免疫组织化学染色显示主细胞表达嗜铬素 A(CgA)、突触素(Syn)、神经细胞黏附分子 56(CD56)、不表达细胞角蛋白(CK)，支持细胞表达酸性钙结合蛋白(S? 100)。与其余 46例肾上腺外副神经节瘤相比，发生肝转移者无特殊病理形态学特征。结论肾上腺外副神经节瘤组织学形态与生物学行为不一。所有肿瘤均有转移潜能，需要长期随访。 |
| 英文摘要: |
| Objective To investigate the clinicopathologic features and biological behaviors of extra?adrenal paraganglioma.Meth? ods Analysis was made of the clinical manifestations，histological characteristics and immunohistochemical results in 47 cases ofextra?adrenal paraganglioma hospitalized in Anhui Provincial Hospital from January 2013 to December 2018.Results There were 23 male and 24 female patients aged 31 to 75 years(mean 51.0 years)in 47 cases.Twenty?four cases occurred in the retroperitone? um，20 cases in the head?and?neck region and 3 cases in the bladder.One paraganglioma case located in the retroperitoneum hadliver metastasis，and the remaining 46 cases were not found with distant metastasis.The tumor was composed of chief cells and sus?tentacular cells.Immunohistochemical staining revealed chief cells intensely positive for neuroendocrine markers such as chromo?granin A(CgA)， synaptophysin(Syn)， neural cell adhesion molecule(CD56)， but negative for cytokeratin(CK).Sustentacular cells were positive for S?100 protein.Compared with the remaining 46 cases of extra?adrenal paraganglioma，the patient with liver metastases showed no special pathological features.Conclusions The histological morphology and biological behavior of the adre?nal paraganglioma are different.All tumors have the potential of metastasis and require long?term follow?up. |
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