| 王晓诺,包香香,陈芳.甲壳质酶蛋白 40、糖类抗原 125和人附睾蛋白 4在子宫内膜癌病人血清中的表达及诊断价值[J].安徽医药,2021,25(9):1766-1770. |
| 甲壳质酶蛋白 40、糖类抗原 125和人附睾蛋白 4在子宫内膜癌病人血清中的表达及诊断价值 |
| Expression and diagnostic value of serum human chitinase-3 like protein 1, carbohydrate antigen 125 and human epididymal protein 4 in patients with endometrial cancer |
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| DOI：10.3969/j.issn.1009-6469.2021.09.016 |
| 中文关键词: 子宫内膜肿瘤 甲壳质酶蛋白 40 糖类抗原 125 人附睾蛋白 4 |
| 英文关键词: Endometrial neoplasms YKL-40 CA125 HE4 |
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| 中文摘要: |
| 目的探讨甲壳质酶蛋白 40(human chitinase-3 like protein 1，YKL-40)、糖类抗原 125(carbohydrate antigen 125， CA125)及人附睾蛋白 4(human epididymal protein 4，HE4)在子宫内膜癌病人血清中的表达特点及诊断价值。方法选取潍坊市人民医院 2017年 9月至 2019年 12月收治的子宫内膜癌病人 51例为试验组，同期子宫良性病变(子宫内膜息肉、子宫肌瘤)病人 40例为对照组。采用酶联免疫吸附测定( ELISA)、直接化学发光法检测 YKL-40、CA125和 HE4在血清中的表达，分析三者在子宫内膜癌病人血清中的诊断效能以及与临床病理因素的关系。结果试验组病人的术前血清 YKL-40、CA125、HE4水平［( 104.56±42.17)μg/L、(22.06±9.72)U/mL、(87.54±26.09)pmol/L］均显著高于对照组［( 34.65±13.96)μg/L、(8.23±3.60)U/mL、 |
| 英文摘要: |
| Objective To investigate the expression and clinical significance of serum human chitinase-3 like protein 1 (YKL-40), carbohydrate antigen 125 (CA125) and human epididymal protein 4 (HE4) in patients with endometrial cancer.Methods Fifty-one patients with endometrial cancer admitted to People's Hospital of Weifang from September 2017 to December 2019 were selected as theexperimental group, and 40 patients with benign uterine lesions (endometrial polyps and uterine fibroids) during the same period wereselected as the control group. Expressions of serum YKL-40, CA125 and HE4 were detected by enzyme-linked immunosorbent assay(ELISA) and direct chemiluminescence methods. The diagnostic efficacy of the three in the serum of patients with endometrial cancerand their relationship with clinicopathological factors were analyzed.Results The preoperative serum levels of YKL-40, CA125, andHE4 in the test group patients [(104.56±42.17) μg/L, (22.06±9.72) U/mL, (87.54±26.09) pmol/L] were significantly higher than those inthe control group [(34.65±13.96) μg/L, (8.23±3.60) U/mL, (50.43±18.92) pmol/L]. The expression of serum YKL-40 in the test groupwas related to the surgical pathological stage and pathological type. The expression of CA125 was related to surgical pathological stage.The expression of HE4 was related to the depth of myometrial invasion,surgical pathological stage,lymph node metastasis, and vascularinfiltration. Serum YKL-40 was positively correlated with CA125 and HE4 (r=0.345, P=0.001; r=0.507, P<0.001). The AUC (95% CI) of serum YKL-40, CA125 and HE4 were 0.882 (0.800-0.967), 0.770 (0.580-0.964) and 0.813 (0.691-0.936), respectively. The combined application of the three indexes had the highest efficiency, with AUC (95%CI) of 0.930 (0.902-0.945).Conclusions YKL-40 and HE4 are expected to become endometrial cancer tumor markers. The combination of YKL-40, CA125, and HE 4 has potential value in the detection of endometrial cancer. |
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