| 曾群章,韩琳,薛吓娟,等.神经突起导向因子 -1蛋白在结直肠癌组织中的表达与临床病理特征及预后的关系[J].安徽医药,2021,25(9):1801-1805. |
| 神经突起导向因子 -1蛋白在结直肠癌组织中的表达与临床病理特征及预后的关系 |
| Expression of netrin-1 protein in colorectal cancer tissues and its relationship with clinical pathological characteristics and prognosis |
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| DOI：10.3969/j.issn.1009-6469.2021.09.024 |
| 中文关键词: 结直肠肿瘤 神经突起导向因子 -1 临床病理特征 预后 |
| 英文关键词: Colorectal neoplasms Netrin-1 Clinical pathological characteristics Prognosis |
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| 中文摘要: |
| 目的探讨神经突起导向因子 -1(netrin-1)蛋白在结直肠癌组织中的表达与临床病理特征及预后的关系。方法按照随机数字表法选取 2012年 1月至 2014年 6月福建省漳州市医院收治的 184例行结直肠癌根治术病人作为研究对象，免疫组织化学染色检测癌组织及癌旁正常组织中 netrin-1的表达，比较其表达差异，并分析其与临床病理特征及预后的相关性。结果癌组织与癌旁正常组织中 netrin-1高表达率分别为 71.7%(132/184)、9.8%(18/184)，差异有统计学意义( χ2=146.255，P<0.001)。 netrin-1高表达与浸润深度( χ2=11.580，P=0.001)、 TNM分期( χ2=8.875，P=0.003)、淋巴结转移( χ2=15.692，P<0.001)有关，而与性别、年龄、肿瘤部位、肿瘤直径、分化程度、病理学类型无关( P>0.05)。 netrin-1高表达与低表达者 5年总生存率分别为 40.9%(54/132)和 71.2%(37/52)，差异有统计学意义( χ2=15.101，P<0.001)。单因素分析显示浸润深度( χ2=4.874，P=0.027)、 TNM分期( χ2=9.215，P=0.002)、淋巴结转移( χ2=14.414，P<0.001)、 netrin-1表达( χ2=15.101，P<0.001)与结直肠癌病人 5年总生存率相关。 Cox多因素分析显示 TNM分期( RR=1.768，95%CI:1.083~2.887，P=0.023)、淋巴结转移( RR=1.946，95%CI:1.193~3.175，P=0.008)、 netrin-1表达( RR=1.959，95%CI:1.034~3.709，P=0.039)是结直肠癌病人的独立预后因素。结论 netrin-1在结直肠癌组织中表达升高，其高表达可能参与结直肠癌的发生发展，对预后判断有一定的参考价值。 |
| 英文摘要: |
| Objective To explore the expression of netrin-1 protein in colorectal cancer tissues and its relationship with clinical pathological characteristics and prognosis.Methods Using random number table method, a total of 184 patients undergoing radicalmastectomy for colorectal cancer, who were admitted to Zhangzhou Municipal Hospital from January 2012 to June 2014, were selectedas the research objects. The expressions of netrin-1 in cancer tissues and adjacent normal tissues were detected by immunohistochemical staining, the expression levels were compared, and their correlation with clinicopathological characteristics and prognosis were analyzed.Results The high expression rates of netrin-1 in cancer tissues and adjacent normal tissues were 71.7% (132/184) and 9.8% (18/184); the difference was statistically significant (χ2=146.255, P<0.001). The high expression of netrin-1 was related to the depth of infiltration (χ2=11.580, P=0.001), TNM staging (χ2=8.875, P=0.003), and lymph node metastasis (χ2=15.692, P<0.001), yet it was not related to gender, age, tumor site, tumor diameter, degree of differentiation, and pathological type (P>0.05). The 5-year overall survival rates of patients with high and low netrin-1 expression were 40.9% (54/132) and 71.2% (37/52), respectively, and the difference was statistically significant (χ2=15.101, P<0.001). Univariate analysis results showed that the depth of infiltration (χ2=4.874, P=0.027), TNM staging (χ2=9.215, P=0.002), lymph node metastasis (χ2=14.414, P<0.001), and netrin-1 expression (χ2=15.101, P<0.001) were related to the 5-year overall survival of patients with colorectal cancer. Cox multivariate analysis results showed that TNM staging (RR=1.768, 95%CI: 1.083-2.887, P=0.023), lymph node metastasis (RR=1.946, 95%CI: 1.193-3.175, P=0.008), netrin-1 expression (RR=1.959, 95%CI: 1.034-3.709, P=0.039) were independent prognostic factors for patients with colorectal cancer.Conclusion Netrin-1 expression is elevated in colorectal cancer tissues, and its high expression may be involved in the occurrence and development of colorectalcancer, which has certain reference value for judging prognosis. |
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